HitPredict

Interactor 1: PROF2 (P35080)
Profilin-2 (Profilin II)
Gene: PFN2

Interactor 2: ENAH (Q8N8S7)
Protein enabled homolog
Gene: ENAH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005856 - cytoskeleton
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 591
+	Hs
		430264 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ENAH_HUMAN (1-591): 2.13e-77: 258: 100.00
+	Mm
		936836 PROF2_MOUSE (1-140): 3.3e-76: 224: 99.29		VASP_MOUSE (380-590): 1.28e-29: 122: 33.18
+	Hs
		430194 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		ITSN1_HUMAN (124-263): 2.96e-29: 125: 37.59
+	Hs
		715013 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		EVL_HUMAN (1-374): 7.41e-27: 115: 32.71
+	Hs
		430372 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		EVL_HUMAN (1-374): 7.41e-27: 115: 32.71
+	Hs
		430285 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		TITIN_HUMAN (81-495): 1.61e-25: 114: 11.06
+	Hs
		714941 PROF2_HUMAN (1-140): 2.83e-76: 224: 100.00		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Hs
		430098 PROF1_HUMAN (1-140): 4.25e-74: 219: 61.43		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Mm
		975407 PROF2_MOUSE (1-140): 3.3e-76: 224: 99.29		ENAH_MOUSE (242-591): 1.85e-17: 88.4: 74.57
+	Mm
		923919 PROF1_MOUSE (1-140): 1.25e-73: 217: 62.86		ENAH_MOUSE (242-591): 1.85e-17: 88.4: 74.57