HitPredict

Interactor 1: UBC2 (P35129)
Ubiquitin-conjugating enzyme E2 2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Lethal protein 70) (Ubiquitin carrier protein 2) (Ubiquitin-protein ligase 2)
Gene: let-70

Interactor 2: OTUBL (Q9XVR6)
Ubiquitin thioesterase otubain-like (EC 3.4.19.12) (Deubiquitinating enzyme otubain-like) (Ubiquitin-specific-processing protease otubain-like)
Gene: otub-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.40	1.00	0.637

Property	Details
Experiments	14704431
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Peptidase_C65~UQ_con
Common GO terms	GO:0005634 - nucleus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 147 Ce			1 284
+	Hs
		1291615 UB2D4_HUMAN (1-147): 3.06e-83: 242: 92.52		OTUB1_HUMAN (2-273): 2.32e-123: 354: 34.42
+	Hs
		849408 UB2D1_HUMAN (1-147): 2.25e-82: 240: 89.12		OTUB1_HUMAN (2-273): 2.32e-123: 354: 34.42
+	Hs
		919824 UB2D2_HUMAN (1-147): 5.79e-82: 239: 93.88		OTUB1_HUMAN (2-273): 2.32e-123: 354: 34.42
+	Hs
		895878 UB2D3_HUMAN (1-147): 8.04e-81: 236: 92.52		OTUB1_HUMAN (2-273): 2.32e-123: 354: 34.42
+	Hs
		1291545 UB2E2_HUMAN (4-146): 3.55e-74: 221: 66.43		OTUB1_HUMAN (2-273): 2.32e-123: 354: 34.42
+	Hs
		1282326 UB2E3_HUMAN (4-146): 1.22e-73: 220: 66.43		OTUB1_HUMAN (2-273): 2.32e-123: 354: 34.42
+	Hs
		851868 UB2E1_HUMAN (4-146): 4.54e-72: 216: 66.43		OTUB1_HUMAN (2-273): 2.32e-123: 354: 34.42
+	Hs
		896520 UBE2N_HUMAN (4-147): 1.25e-68: 205: 47.22		OTUB1_HUMAN (2-273): 2.32e-123: 354: 34.42
+	Mm
		896585 UBE2N_MOUSE (4-147): 1.25e-68: 205: 47.22		OTUB1_MOUSE (2-273): 2.05e-123: 354: 34.42
+	Hs
		896513 UBE2N_HUMAN (4-147): 1.25e-68: 205: 47.22		OTUB2_HUMAN (52-275): 6.51e-99: 291: 29.46
+	At
		1228110 UBC36_ARATH (4-146): 4.51e-43: 140: 49.65		OTU1_ARATH (28-281): 2.59e-118: 343: 35.42