HitPredict

Interactor 1: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Interactor 2: LEF1 (Q9UJU2)
Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)
Gene: LEF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 21743491, 29374064, 19223551, 8757136, 10890911, 33431799, 16510874, 16510875, 18296023, 9419974, 15525529, 15684397, 27684187, 12748295, 37303493, 16204248, 10958684, 11835406, 12077367, 15768032 and 6 others

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Identification Methods affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Arm~CTNNB1_binding, Arm~HMG_box
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001222 - transcription corepressor binding
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001649 - osteoblast differentiation
GO:0001837 - epithelial to mesenchymal transition
and 20 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 781
Hs

1 399
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+ Ce
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024