Protein: GPC3
Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]

Gene: GPC3
Organism: Homo sapiens
Interactions: 222
UniProt ID: P51654

Gene Ontology (top 5):
GO:0001658 - branching involved in ureteric bud morphogenesis
GO:0005788 - endoplasmic reticulum lumen
GO:0005796 - Golgi lumen
GO:0005886 - plasma membrane
GO:0007224 - smoothened signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733489

GP183
G-protein coupled receptor 183

3

7

High-throughput

0.667

High

906273

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

8

Small-scale

0.647

High

906267

LMAN2
Vesicular integral-membrane protein VIP36

3

0

High-throughput

0.638

High

426945

FGF1
Fibroblast growth factor 1

2

8

High-throughput

0.628

High

906324

CAMKV
CaM kinase-like vesicle-associated protein

2

3

High-throughput

0.628

High

906347

ULBP1
UL16-binding protein 1

2

3

High-throughput

0.628

High

906341

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

2

1

High-throughput

0.611

High

212898

LRRT2
Leucine-rich repeat transmembrane neuronal protein 2

3

12

High-throughput

0.609

High

698503

CALX
Calnexin

2

4

High-throughput

0.601

High

898365

BCAM
Basal cell adhesion molecule

1

3

High-throughput

0.575

High

906282

ODAPH
Odontogenesis associated phosphoprotein

2

1

High-throughput

0.574

High

906349

TSYL1
Testis-specific Y-encoded-like protein 1

2

1

High-throughput

0.574

High

170707

CLGN
Calmegin

2

4

High-throughput

0.549

High

50363

PXDNL
Probable oxidoreductase PXDNL

1

0

High-throughput

0.546

High

378776

LV147
Immunoglobulin lambda variable 1-47

1

0

High-throughput

0.546

High

390245

FETA
Alpha-fetoprotein

1

0

High-throughput

0.545

High

193533

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

3

High-throughput

0.536

High

437648

HEPS
Serine protease hepsin

1

11

High-throughput

0.536

High

472393

FGF4
Fibroblast growth factor 4

1

8

High-throughput

0.536

High

583230

FOLR1
Folate receptor alpha

1

1

High-throughput

0.536

High

897155

TUB
Tubby protein homolog

1

4

High-throughput

0.536

High

906287

ULBP6
UL16-binding protein 6

1

3

High-throughput

0.536

High

906335

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.536

High

906360

COKA1

1

9

High-throughput

0.536

High

906379

ST14
Suppressor of tumorigenicity 14 protein

1

11

High-throughput

0.536

High

906368

DP13A
DCC-interacting protein 13-alpha

1

0

High-throughput

0.518

High

906308

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.514

High

648268

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

0

High-throughput

0.513

High

719887

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.513

High

906256

RAP1A
Ras-related protein Rap-1A

1

0

High-throughput

0.513

High

906271

NOGG
Noggin

1

0

High-throughput

0.513

High

906312

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.513

High

906355

NRN1
Neuritin

1

0

High-throughput

0.513

High

906378

LIPG
Endothelial lipase

1

0

High-throughput

0.513

High

421752

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.501

High

154805

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

4

High-throughput

0.489

High

829321

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

7

High-throughput

0.489

High

906260

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.489

High

906272

SG2A2
Mammaglobin-A

1

2

High-throughput

0.489

High

906283

CL12B
C-type lectin domain family 12 member B

1

6

High-throughput

0.489

High

906290

TRI68
E3 ubiquitin-protein ligase TRIM68

1

1

High-throughput

0.489

High

906310

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

13

High-throughput

0.489

High

906311

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

13

High-throughput

0.489

High

906334

REEP6
Receptor expression-enhancing protein 6

1

1

High-throughput

0.489

High

906350

XYLT2
Xylosyltransferase 2

1

1

High-throughput

0.489

High

906364

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.489

High

906294

NOTUM
Palmitoleoyl-protein carboxylesterase NOTUM

1

0

Small-scale

0.480

High

279313

TULP3
Tubby-related protein 3

1

4

High-throughput

0.479

High

400512

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

478457

FGF2
Fibroblast growth factor 2

1

8

Small-scale

0.479

High

906351

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

1

Small-scale

0.479

High

446786

NPM
Nucleophosmin

1

1

High-throughput

0.470

High

906259

VIGLN
Vigilin

1

0

High-throughput

0.458

High

906346

RAB34
Ras-related protein Rab-34

1

0

High-throughput

0.458

High

130047

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.445

High

144001

P3C2B
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

1

1

High-throughput

0.445

High

188079

MOT5
Monocarboxylate transporter 5

1

2

High-throughput

0.445

High

379955

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

424164

S10A8
Protein S100-A8

1

5

High-throughput

0.445

High

444936

S10A9
Protein S100-A9

1

5

High-throughput

0.445

High

452207

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.445

High

455906

ASGR1
Asialoglycoprotein receptor 1

1

6

High-throughput

0.445

High

571401

GLU2B
Glucosidase 2 subunit beta

1

1

High-throughput

0.445

High

647322

ACES
Acetylcholinesterase

1

2

High-throughput

0.445

High

654454

EST1
Liver carboxylesterase 1

1

2

High-throughput

0.445

High

669090

GUC2C
Guanylyl cyclase C

1

1

High-throughput

0.445

High

683976

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

10

High-throughput

0.445

High

713347

SPB3
Serpin B3

1

3

High-throughput

0.445

High

717411

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.445

High

775754

ATP7B
Copper-transporting ATPase 2

1

1

High-throughput

0.445

High

834939

S19A1
Reduced folate transporter

1

1

High-throughput

0.445

High

874763

SPB4
Serpin B4

1

3

High-throughput

0.445

High

906252

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

906262

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.445

High

906263

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

High-throughput

0.445

High

906275

FAT1
Protocadherin Fat 1

1

2

High-throughput

0.445

High

906296

ISLR2
Immunoglobulin superfamily containing leucine-rich repeat protein 2

1

4

High-throughput

0.445

High

906304

CNTRL
Centriolin

1

2

High-throughput

0.445

High

906305

DSG4
Desmoglein-4

1

3

High-throughput

0.445

High

906344

PRAX
Periaxin

1

1

High-throughput

0.445

High

906373

PKP3
Plakophilin-3

1

1

High-throughput

0.445

High

906377

MRCKB
Serine/threonine-protein kinase MRCK beta

1

3

High-throughput

0.445

High

830378

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

906292

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.437

High

906352

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.437

High

171419

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.426

High

222257

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

229678

CALU
Calumenin

1

0

High-throughput

0.426

High

270904

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.426

High

321207

ERLN2
Erlin-2

1

0

High-throughput

0.426

High

337076

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

456210

CATD
Cathepsin D

1

0

High-throughput

0.426

High

548446

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.426

High

800465

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.426

High

810592

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

0

High-throughput

0.426

High

906254

ENK25
Endogenous retrovirus group K member 25 Env polyprotein

1

0

High-throughput

0.426

High

906285

SRCRM
Scavenger receptor cysteine-rich domain-containing protein SCART1

1

0

High-throughput

0.426

High

906289

FMN1
Formin-1

1

0

High-throughput

0.426

High

906329

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.426

High

906331

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.426

High

906342

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.426

High

906345

S26A6
Solute carrier family 26 member 6

1

0

High-throughput

0.426

High

906353

PIEZ2
Piezo-type mechanosensitive ion channel component 2

1

0

High-throughput

0.426

High

906354

MYO10
Unconventional myosin-X

1

0

High-throughput

0.426

High

906361

ATX10
Ataxin-10

1

0

High-throughput

0.426

High

906362

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.426

High

906363

ZO2
Tight junction protein 2

1

0

High-throughput

0.426

High

906365

ADDG
Gamma-adducin

1

0

High-throughput

0.426

High

906371

RUVB2
RuvB-like 2

1

0

High-throughput

0.426

High

906375

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.426

High

64971

SWAHB
Ankyrin repeat domain-containing protein SOWAHB

1

4

High-throughput

0.407

High

75875

B4DE62
cDNA FLJ61693, highly similar to Transducin-like enhancer protein 2

1

2

High-throughput

0.407

High

181287

PGRC2
Membrane-associated progesterone receptor component 2

1

1

High-throughput

0.407

High

207700

SGSM2
Small G protein signaling modulator 2

1

1

High-throughput

0.407

High

255775

USO1
General vesicular transport factor p115

1

2

High-throughput

0.407

High

256600

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

2

High-throughput

0.407

High

365337

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.407

High

369543

ANGT
Angiotensinogen

1

3

High-throughput

0.407

High

457849

INVO
Involucrin

1

1

High-throughput

0.407

High

462310

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

High-throughput

0.407

High

551700

HARS1
Histidine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

586208

IGLL1
Immunoglobulin lambda-like polypeptide 1

1

1

High-throughput

0.407

High

586592

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.407

High

586976

CHIN
N-chimaerin

1

1

High-throughput

0.407

High

596003

H12
Histone H1.2

1

1

High-throughput

0.407

High

725771

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

1

High-throughput

0.407

High

754767

H2B1B
Histone H2B type 1-B

1

2

High-throughput

0.407

High

787623

SPB5
Serpin B5

1

3

High-throughput

0.407

High

906265

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.407

High

906266

ILF2
Interleukin enhancer-binding factor 2

1

1

High-throughput

0.407

High

906269

CSN1
COP9 signalosome complex subunit 1

1

1

High-throughput

0.407

High

906270

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

1

High-throughput

0.407

High

906274

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.407

High

906276

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.407

High

906279

BATF
Basic leucine zipper transcriptional factor ATF-like

1

2

High-throughput

0.407

High

906291

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.407

High

906293

EDC4
Enhancer of mRNA-decapping protein 4

1

1

High-throughput

0.407

High

906297

CP26C
Cytochrome P450 26C1

1

1

High-throughput

0.407

High

906298

UBN2
Ubinuclein-2

1

1

High-throughput

0.407

High

906301

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

1

High-throughput

0.407

High

906303

BMP8A
Bone morphogenetic protein 8A

1

1

High-throughput

0.407

High

906316

CCD13
Coiled-coil domain-containing protein 13

1

2

High-throughput

0.407

High

906320

IGSF1
Immunoglobulin superfamily member 1

1

2

High-throughput

0.407

High

906323

F184A
Protein FAM184A

1

1

High-throughput

0.407

High

906327

HS105
Heat shock protein 105 kDa

1

2

High-throughput

0.407

High

906328

EVPL
Envoplakin

1

3

High-throughput

0.407

High

906333

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

2

High-throughput

0.407

High

906337

SPB11
Serpin B11

1

3

High-throughput

0.407

High

906366

DNJ5B
DnaJ homolog subfamily C member 5B

1

1

High-throughput

0.407

High

906369

RALY
RNA-binding protein Raly

1

2

High-throughput

0.407

High

906374

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.407

High

906376

HECD4
Probable E3 ubiquitin-protein ligase HECTD4

1

2

High-throughput

0.407

High

906321

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

906280

TAZ
Tafazzin

2

0

High-throughput

0.318

High

183139

GNPAT
Dihydroxyacetone phosphate acyltransferase

1

0

High-throughput

0.279

Low

327201

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.279

Low

416601

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.279

Low

665080

COT2
COUP transcription factor 2

1

0

High-throughput

0.279

Low

879994

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.279

Low

906277

ZN460
Zinc finger protein 460

1

0

High-throughput

0.279

Low

906286

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.279

Low

906295

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.279

Low

906317

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

0

High-throughput

0.279

Low

906319

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.279

Low

906330

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

0

High-throughput

0.279

Low

906332

TM186
Transmembrane protein 186

1

0

High-throughput

0.279

Low

906336

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

906348

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.279

Low

906356

PRD10
PR domain zinc finger protein 10

1

0

High-throughput

0.279

Low

906367

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.279

Low

95824

FONG
Formiminotransferase N-terminal subdomain-containing protein

1

0

High-throughput

0.232

Low

158156

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.232

Low

210894

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.232

Low

239358

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

0

High-throughput

0.232

Low

249282

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

High-throughput

0.232

Low

251726

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.232

Low

337166

APOM
Apolipoprotein M

1

0

High-throughput

0.232

Low

378479

IL1A
Interleukin-1 alpha

1

0

High-throughput

0.232

Low

483543

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.232

Low

515753

NARR
Ras-related protein Rab-34, isoform NARR

1

0

High-throughput

0.232

Low

517212

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low

592816

CBR1
Carbonyl reductase [NADPH] 1

1

0

High-throughput

0.232

Low

616156

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.232

Low

627118

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.232

Low

773457

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.232

Low

789880

FDFT
Squalene synthase

1

0

High-throughput

0.232

Low

860095

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.232

Low

873185

COPD
Coatomer subunit delta

1

0

High-throughput

0.232

Low

904261

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.232

Low

906253

ARP3
Actin-related protein 3

1

0

High-throughput

0.232

Low

906255

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.232

Low

906257

SRSF3
Serine/arginine-rich splicing factor 3

1

0

High-throughput

0.232

Low

906258

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.232

Low

906261

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

1

0

High-throughput

0.232

Low

906264

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.232

Low

906268

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.232

Low

906278

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.232

Low

906281

H31T
Histone H3.1t

1

0

High-throughput

0.232

Low

906284

ZN630
Zinc finger protein 630

1

0

High-throughput

0.232

Low

906288

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

906299

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.232

Low

906300

BEND5
BEN domain-containing protein 5

1

0

High-throughput

0.232

Low

906302

TRM1L
tRNA

1

0

High-throughput

0.232

Low

906306

GTD2A
General transcription factor II-I repeat domain-containing protein 2A

1

0

High-throughput

0.232

Low

906307

CASZ1
Zinc finger protein castor homolog 1

1

0

High-throughput

0.232

Low

906309

KIF27
Kinesin-like protein KIF27

1

0

High-throughput

0.232

Low

906313

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.232

Low

906314

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.232

Low

906315

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

0

High-throughput

0.232

Low

906318

RDHE2
Epidermal retinol dehydrogenase 2

1

0

High-throughput

0.232

Low

906322

YP023
Putative uncharacterized protein FLJ34945

1

0

High-throughput

0.232

Low

906325

MFSD8
Major facilitator superfamily domain-containing protein 8

1

0

High-throughput

0.232

Low

906326

NCOA7
Nuclear receptor coactivator 7

1

0

High-throughput

0.232

Low

906338

H2A1A
Histone H2A type 1-A

1

0

High-throughput

0.232

Low

906339

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.232

Low

906340

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.232

Low

906343

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

High-throughput

0.232

Low

906357

FBX6
F-box only protein 6

1

0

High-throughput

0.232

Low

906358

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.232

Low

906359

HACD3
Very-long-chain

1

0

High-throughput

0.232

Low

906370

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.232

Low

906372

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025