HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	26151332, 33589814, 21772249, 16714294, 24614341
Identification Methods	pull down, x-ray crystallography
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 147
+	Hs
		717650 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		718384 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		718419 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		UB2E2_HUMAN (4-146): 1.76e-74: 222: 65.04
+	Hs
		895802 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		1108530 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		UB2E3_HUMAN (4-146): 1.05e-73: 220: 65.73
+	Hs
		895898 PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		895893 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		584907 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		584923 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		895830 PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		584916 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		849314 TRI26_HUMAN (5-210): 1e-49: 175: 16.59		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		849366 TRI22_HUMAN (1-198): 2.92e-50: 175: 14.56		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		919712 TRI26_HUMAN (5-210): 1e-49: 175: 16.59		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		895782 TRI26_HUMAN (5-210): 1e-49: 175: 16.59		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		849439 TRIM5_HUMAN (9-190): 3.01e-48: 170: 14.89		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		895905 TRIM5_HUMAN (9-190): 3.01e-48: 170: 14.89		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		851832 PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04
+	Hs
		584910 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04
+	Hs
		584918 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		UBE2N_HUMAN (4-147): 3.74e-68: 204: 46.53