HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: CHD3 (Q12873)
Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)
Gene: CHD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	24457600, 34316702
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0008270 - zinc ion binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 2000
+	Hs
		1018655 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		CHD3_HUMAN (1-2000): 0: 1917: 100.00
+	Hs
		717833 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CHD4_HUMAN (132-1922): 0: 1552: 69.84
+	Hs
		1059848 PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12		CHD4_HUMAN (132-1922): 0: 1552: 69.84
+	Hs
		1059817 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		CHD4_HUMAN (132-1922): 0: 1552: 69.84
+	Hs
		282655 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		CHD4_HUMAN (132-1922): 0: 1552: 69.84
+	Hs
		229323 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		SMCA5_HUMAN (584-1612): 0: 778: 27.17
+	Hs
		717581 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		SMCA2_HUMAN (73-1644): 0: 718: 20.07
+	Mm
		1265292 RING2_MOUSE (7-227): 5.77e-50: 171: 16.61		SMCA5_MOUSE (612-1612): 0: 781: 28.28
+	Hs
		229473 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		SMCA5_HUMAN (584-1612): 0: 778: 27.17