Protein: 2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)

Gene: 2AAB, PPP2R1B
Organism: Homo sapiens
Interactions: 169
UniProt ID: P30154

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019888 - protein phosphatase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718101

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

9

20

Small-scale

0.979

High

718098

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

8

20

Small-scale

0.975

High

717689

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

8

4

Small-scale

0.965

High

228553

STRN
Striatin

5

18

Small-scale

0.932

High

718124

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

5

20

Small-scale

0.931

High

718112

STRN3
Striatin-3

5

20

Small-scale

0.930

High

718121

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

5

20

Small-scale

0.925

High

138810

STK25
Serine/threonine-protein kinase 25

3

14

High-throughput

0.871

High

718206

STK24
Serine/threonine-protein kinase 24

3

17

High-throughput

0.871

High

718106

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

3

9

Small-scale

0.861

High

718127

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

3

20

Small-scale

0.858

High

718114

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

3

20

Small-scale

0.839

High

718125

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

2

20

Small-scale

0.789

High

718078

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

2

4

High-throughput

0.775

High

718200

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

7

10

High-throughput

0.748

High

718099

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

6

10

Small-scale

0.737

High

718204

P2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

1

9

Small-scale

0.724

High

718133

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

5

10

High-throughput

0.722

High

718103

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

4

10

High-throughput

0.701

High

58705

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

4

10

High-throughput

0.694

High

176800

DCLK1
Serine/threonine-protein kinase DCLK1

1

7

High-throughput

0.691

High

443206

CDK1
Cyclin-dependent kinase 1

1

3

Small-scale

0.691

High

549066

CDK4
Cyclin-dependent kinase 4

1

5

Small-scale

0.691

High

718094

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

High-throughput

0.691

High

718135

PKN3
Serine/threonine-protein kinase N3

1

2

High-throughput

0.691

High

718153

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

6

High-throughput

0.691

High

718164

PSKH2
Serine/threonine-protein kinase H2

1

7

High-throughput

0.691

High

718186

STK26
Serine/threonine-protein kinase 26

1

15

High-throughput

0.691

High

718198

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

7

High-throughput

0.691

High

221917

FOXS1
Forkhead box protein S1

3

11

High-throughput

0.667

High

718150

ZN114
Zinc finger protein 114

3

5

High-throughput

0.667

High

718170

IER2
Immediate early response gene 2 protein

3

3

High-throughput

0.667

High

718183

SRTD4
SERTA domain-containing protein 4

3

1

High-throughput

0.667

High

718189

ZN219
Zinc finger protein 219

3

3

High-throughput

0.667

High

718111

FOXD4
Forkhead box protein D4

3

11

High-throughput

0.662

High

563270

CFTR
Cystic fibrosis transmembrane conductance regulator

3

6

High-throughput

0.656

High

718130

SGO2
Shugoshin 2

3

1

Small-scale

0.650

High

718091

WNT3A
Protein Wnt-3a

3

0

High-throughput

0.638

High

718141

ZN550
Zinc finger protein 550

2

2

High-throughput

0.628

High

718173

CDCA4
Cell division cycle-associated protein 4

2

5

High-throughput

0.628

High

718181

ZN331
Zinc finger protein 331

2

3

High-throughput

0.628

High

718185

TBCC1
TBCC domain-containing protein 1

2

3

High-throughput

0.628

High

718089

DAPK1
Death-associated protein kinase 1

1

9

Small-scale

0.618

High

718113

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

9

Small-scale

0.618

High

718136

INT5
Integrator complex subunit 5

1

1

High-throughput

0.618

High

718147

INT1
Integrator complex subunit 1

1

1

High-throughput

0.618

High

718168

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

7

High-throughput

0.618

High

718192

XPO7
Exportin-7

1

5

High-throughput

0.618

High

718148

FA43A
Protein FAM43A

3

1

High-throughput

0.609

High

718197

T3JAM
TRAF3-interacting JNK-activating modulator

3

6

High-throughput

0.604

High

718196

TRI35
E3 ubiquitin-protein ligase TRIM35

2

0

High-throughput

0.602

High

341902

CEP43
Centrosomal protein 43

2

1

Small-scale

0.601

High

718131

SGO1
Shugoshin 1

2

1

High-throughput

0.601

High

718169

SIKE1
Suppressor of IKBKE 1

2

3

High-throughput

0.601

High

718126

CRY1
Cryptochrome-1

2

4

High-throughput

0.586

High

718195

INT6
Integrator complex subunit 6

2

3

Small-scale

0.584

High

718145

ULK2
Serine/threonine-protein kinase ULK2

1

11

High-throughput

0.575

High

718175

SIK2
Serine/threonine-protein kinase SIK2

1

11

Small-scale

0.575

High

718182

STRN4
Striatin-4

1

17

High-throughput

0.575

High

718172

PRR14
Proline-rich protein 14

2

5

High-throughput

0.574

High

718156

BAD
Bcl2-associated agonist of cell death

2

1

High-throughput

0.571

High

718201

PHOCN
MOB-like protein phocein

1

7

High-throughput

0.554

High

192900

CLOCK
Circadian locomoter output cycles protein kaput

1

4

High-throughput

0.552

High

718146

UNC5B
Netrin receptor UNC5B

1

2

Small-scale

0.552

High

69762

ZN785
Zinc finger protein 785

1

5

High-throughput

0.536

High

130385

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.536

High

476098

ANXA5
Annexin A5

1

1

Small-scale

0.536

High

503555

TFPT
TCF3 fusion partner

1

1

High-throughput

0.536

High

539776

RALA
Ras-related protein Ral-A

1

12

Small-scale

0.536

High

541847

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

565786

EF2
Elongation factor 2

1

6

Small-scale

0.536

High

621819

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.536

High

665950

IBP5
Insulin-like growth factor-binding protein 5

1

1

High-throughput

0.536

High

669822

MCM3
DNA replication licensing factor MCM3

1

8

Small-scale

0.536

High

718079

PRDX2
Peroxiredoxin-2

1

4

Small-scale

0.536

High

718085

KSYK
Tyrosine-protein kinase SYK

1

12

High-throughput

0.536

High

718086

RAB7A
Ras-related protein Rab-7a

1

8

Small-scale

0.536

High

718090

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

718097

RB11A
Ras-related protein Rab-11A

1

4

Small-scale

0.536

High

718100

DYL1
Dynein light chain 1, cytoplasmic

1

5

High-throughput

0.536

High

718107

PRDX1
Peroxiredoxin-1

1

4

Small-scale

0.536

High

718108

SSRP1
FACT complex subunit SSRP1

1

5

High-throughput

0.536

High

718109

NCBP1
Nuclear cap-binding protein subunit 1

1

3

High-throughput

0.536

High

718116

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.536

High

718117

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

718118

SRTD2
SERTA domain-containing protein 2

1

3

High-throughput

0.536

High

718122

SLMAP
Sarcolemmal membrane-associated protein

1

6

High-throughput

0.536

High

718128

FX4L6
Forkhead box protein D4-like 6

1

11

High-throughput

0.536

High

718138

NPSR1
Neuropeptide S receptor

1

2

High-throughput

0.536

High

718151

COP1
E3 ubiquitin-protein ligase COP1

1

8

High-throughput

0.536

High

718158

PBIR1
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

1

2

High-throughput

0.536

High

718162

CEP19
Centrosomal protein of 19 kDa

1

1

High-throughput

0.536

High

718166

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.536

High

718167

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.536

High

718171

PDC10
Programmed cell death protein 10

1

1

High-throughput

0.536

High

718177

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

718180

RAB18
Ras-related protein Rab-18

1

4

Small-scale

0.536

High

718184

FGOP2
FGFR1 oncogene partner 2

1

3

High-throughput

0.536

High

718187

CT2NL
CTTNBP2 N-terminal-like protein

1

4

High-throughput

0.536

High

718190

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.536

High

718191

SRTD1
SERTA domain-containing protein 1

1

1

High-throughput

0.536

High

167231

KLF11
Krueppel-like factor 11

1

5

High-throughput

0.515

High

718095

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

718087

RORG
Nuclear receptor ROR-gamma

1

3

High-throughput

0.508

High

718102

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

185454

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

507572

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.501

High

718080

NUP62
Nuclear pore glycoprotein p62

1

6

Small-scale

0.501

High

274476

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.493

High

718084

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.489

High

718110

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

2

High-throughput

0.489

High

718123

P2RY6
P2Y purinoceptor 6

1

9

High-throughput

0.489

High

718140

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

High-throughput

0.489

High

718176

CA021
Uncharacterized protein C1orf21

1

1

High-throughput

0.489

High

718202

CCDC9
Coiled-coil domain-containing protein 9

1

1

High-throughput

0.489

High

718205

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

718129

CRY2
Cryptochrome-2

1

4

High-throughput

0.481

High

718174

BHE41
Class E basic helix-loop-helix protein 41

1

2

High-throughput

0.481

High

718194

FBW1B
F-box/WD repeat-containing protein 11

1

7

High-throughput

0.481

High

219698

FOXO3
Forkhead box protein O3

1

5

Small-scale

0.479

High

222751

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

253306

JAK2
Tyrosine-protein kinase JAK2

1

9

Small-scale

0.479

High

315174

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

362833

EGFR
Epidermal growth factor receptor

1

9

High-throughput

0.479

High

536577

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

541357

FGFR1
Fibroblast growth factor receptor 1

1

9

Small-scale

0.479

High

639193

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

7

High-throughput

0.479

High

718081

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

718088

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

718092

FBXW4
F-box/WD repeat-containing protein 4

1

9

Small-scale

0.479

High

718093

ZN445
Zinc finger protein 445

1

3

High-throughput

0.479

High

718096

MAX
Protein max

1

7

Small-scale

0.479

High

718104

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

6

High-throughput

0.479

High

718105

CAV1
Caveolin-1

1

2

Small-scale

0.479

High

718115

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

5

High-throughput

0.479

High

718119

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.479

High

718134

INT3
Integrator complex subunit 3

1

1

High-throughput

0.479

High

718139

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

718149

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

718152

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

1

Small-scale

0.479

High

718154

ASB11
Ankyrin repeat and SOCS box protein 11

1

8

High-throughput

0.479

High

718159

DYL2
Dynein light chain 2, cytoplasmic

1

5

High-throughput

0.479

High

718163

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

718165

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.479

High

718178

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

718203

DCAF1
DDB1- and CUL4-associated factor 1

1

9

Small-scale

0.479

High

718207

NEMO
NF-kappa-B essential modulator

1

2

Small-scale

0.479

High

487979

DPOLA
DNA polymerase alpha catalytic subunit

1

0

Small-scale

0.458

High

718082

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

154943

BHE40
Class E basic helix-loop-helix protein 40

1

2

High-throughput

0.457

High

166256

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

2

High-throughput

0.445

High

171402

S27A2
Long-chain fatty acid transport protein 2

1

8

High-throughput

0.445

High

532389

CH60
60 kDa heat shock protein, mitochondrial

1

2

Small-scale

0.445

High

718083

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.445

High

718120

ESPL1
Separin

1

2

Small-scale

0.445

High

718132

STRP1
Striatin-interacting protein 1

1

4

High-throughput

0.445

High

718144

ZN695
Zinc finger protein 695

1

1

High-throughput

0.445

High

718157

ZN566
Zinc finger protein 566

1

3

High-throughput

0.445

High

718160

TNIP3
TNFAIP3-interacting protein 3

1

1

High-throughput

0.445

High

718179

DOCK5
Dedicator of cytokinesis protein 5

1

2

High-throughput

0.445

High

718188

DEC1
Deleted in esophageal cancer 1

1

1

High-throughput

0.439

High

718161

EP400
E1A-binding protein p400

1

3

Small-scale

0.437

High

718193

ZN223
Zinc finger protein 223

1

0

High-throughput

0.426

High

718137

S27A1
Long-chain fatty acid transport protein 1

1

8

High-throughput

0.407

High

718143

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

718155

CTTB2
Cortactin-binding protein 2

1

13

High-throughput

0.407

High

718199

S27A6
Long-chain fatty acid transport protein 6

1

8

High-throughput

0.407

High

718142

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.328

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025