HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 126
+	Hs
		717646 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707534 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		717607 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		718401 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1087375 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918649 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		1087359 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918631 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707723 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1231231 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Mm
		1145466 CHFR_MOUSE (6-167): 1.07e-33: 132: 19.39		H2B2E_MOUSE (1-126): 1.28e-52: 163: 96.83
+	Hs
		918311 RING1_HUMAN (7-115): 2.38e-30: 120: 25.46		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707600 RING1_HUMAN (7-115): 2.38e-30: 120: 25.46		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		282669 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		282550 RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Mm
		1145467 RNF8_MOUSE (2-102): 4.69e-20: 92.2: 26.73		H2B2E_MOUSE (1-126): 1.28e-52: 163: 96.83