HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: PHC2 (Q8IXK0)
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Gene: PHC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.763

Property	Details
Experiments	25416956, 24457600, 27827373, 25910212, 27705803, 9121482, 33961781, 34316702, 37014752, 19636380, 22325352, 24981860, 16751658, 20601937
Identification Methods	two hybrid, affinity chromatography technology, pull down, x-ray crystallography, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 858
+	Hs
		1220909 R4GMX3_HUMAN (1-326): 5.65e-157: 449: 100.00		PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00
+	Mm
		639480 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		PHC2_MOUSE (1-858): 2.51e-83: 287: 85.40
+	Hs
		718408 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00
+	Mm
		620794 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		PHC2_MOUSE (1-858): 2.51e-83: 287: 85.40
+	Hs
		717684 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40
+	Mm
		639473 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		PHC1_MOUSE (44-858): 4.73e-42: 168: 25.50
+	Hs
		554277 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		MUC1_HUMAN (4-625): 1.16e-31: 135: 11.18
+	Hs
		718098 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		SCMH1_HUMAN (439-857): 3.7e-30: 129: 18.18
+	Hs
		718330 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		SCML2_HUMAN (449-857): 3.15e-29: 126: 16.30
+	Hs
		1108515 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00
+	Dr
		1225025 BMI1A_DANRE (1-326): 9.35e-128: 369: 81.29		PHC2_DANRE (8-858): 4.13e-43: 170: 39.21
+	Dr
		1186373 BMI1B_DANRE (1-322): 4e-124: 360: 77.23		PHC2_DANRE (8-858): 4.13e-43: 170: 39.21
+	Hs
		718390 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40
+	Hs
		718028 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PHC3_HUMAN (12-763): 3.91e-14: 78.9: 23.81
+	Mm
		639476 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		PHC3_MOUSE (13-721): 2.67e-15: 82.7: 24.26
+	Mm
		620786 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		PHC1_MOUSE (44-858): 4.73e-42: 168: 25.50
+	Hs
		718418 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		SCMH1_HUMAN (439-857): 3.7e-30: 129: 18.18
+	Hs
		718412 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PHC3_HUMAN (12-763): 3.91e-14: 78.9: 23.81
+	Mm
		620790 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		PHC3_MOUSE (13-721): 2.67e-15: 82.7: 24.26
+	Hs
		943064 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40