HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: PHC3 (Q8NDX5)
Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)
Gene: PHC3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	24457600, 27705803, 24981860, 33961781, 34316702, 19636380, 22325352, 20601937
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 983
+	Mm
		639476 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		PHC3_MOUSE (30-983): 1.26e-78: 278: 93.61
+	Hs
		718412 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00
+	Hs
		554277 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		MUC1_HUMAN (2-764): 1.79e-44: 177: 11.56
+	Mm
		620790 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		PHC3_MOUSE (30-983): 1.26e-78: 278: 93.61
+	Hs
		718098 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83
+	Hs
		717684 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PHC1_HUMAN (33-983): 9.51e-36: 148: 23.90
+	Hs
		718330 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		SCML2_HUMAN (553-982): 5.47e-34: 141: 17.40
+	Mm
		639473 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		PHC1_MOUSE (33-983): 3.74e-35: 147: 24.25
+	Hs
		718311 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		SCML1_HUMAN (799-982): 6.24e-33: 132: 22.28
+	Hs
		1220909 R4GMX3_HUMAN (1-326): 5.65e-157: 449: 100.00		PHC2_HUMAN (30-566): 3.66e-17: 88.9: 27.02
+	Hs
		717999 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		PHC2_HUMAN (30-566): 3.66e-17: 88.9: 27.02
+	Mm
		639480 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		PHC2_MOUSE (30-635): 2.17e-13: 76.6: 25.74
+	Dr
		1225025 BMI1A_DANRE (1-326): 9.35e-128: 369: 81.29		PHC2_DANRE (172-983): 1.93e-30: 131: 23.58
+	Hs
		718418 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83
+	Hs
		718390 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PHC1_HUMAN (33-983): 9.51e-36: 148: 23.90
+	Dr
		1186373 BMI1B_DANRE (1-322): 4e-124: 360: 77.23		PHC2_DANRE (172-983): 1.93e-30: 131: 23.58
+	Mm
		620786 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		PHC1_MOUSE (33-983): 3.74e-35: 147: 24.25
+	Hs
		718440 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		SCML1_HUMAN (799-982): 6.24e-33: 132: 22.28
+	Hs
		718408 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		PHC2_HUMAN (30-566): 3.66e-17: 88.9: 27.02
+	Mm
		620794 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		PHC2_MOUSE (30-635): 2.17e-13: 76.6: 25.74