Protein: TNPO1
Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)

Gene: TNPO1
Organism: Homo sapiens
Interactions: 230
UniProt ID: Q92973

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

981621

RAN
GTP-binding nuclear protein Ran

6

19

Small-scale

0.944

High

485312

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

9

Small-scale

0.812

High

539897

RALB
Ras-related protein Ral-B

2

7

High-throughput

0.737

High

988586

RAC1
Ras-related C3 botulinum toxin substrate 1

2

11

High-throughput

0.737

High

910614

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

Small-scale

0.716

High

142598

IMA3
Importin subunit alpha-3

1

20

High-throughput

0.691

High

650888

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

7

High-throughput

0.691

High

911035

IMA1
Importin subunit alpha-1

1

20

High-throughput

0.691

High

993691

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.691

High

1134317

IMB1
Importin subunit beta-1

1

10

High-throughput

0.691

High

1370984

TMA16
Translation machinery-associated protein 16

3

2

High-throughput

0.675

High

890382

NU153
Nuclear pore complex protein Nup153

3

20

Small-scale

0.662

High

1278620

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.656

High

242494

PRKN
E3 ubiquitin-protein ligase parkin

3

13

High-throughput

0.640

High

1364494

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

6

Small-scale

0.639

High

1371023

NXF1
Nuclear RNA export factor 1

2

6

Small-scale

0.629

High

775243

FUS
RNA-binding protein FUS

2

5

Small-scale

0.629

High

1120270

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

2

9

Small-scale

0.619

High

164619

TNPO2
Transportin-2

1

10

High-throughput

0.618

High

173167

XPO1
Exportin-1

1

13

Small-scale

0.618

High

775585

NU214
Nuclear pore complex protein Nup214

1

20

Small-scale

0.618

High

1113908

CUL3
Cullin-3

1

9

High-throughput

0.618

High

1135027

CUL7
Cullin-7

1

2

High-throughput

0.618

High

1371002

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.618

High

1209473

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

Small-scale

0.612

High

1371016

SLX9
Ribosome biogenesis protein SLX9 homolog

2

1

Small-scale

0.611

High

1371020

PD1L1
Programmed cell death 1 ligand 1

2

19

High-throughput

0.611

High

1312111

TARG1
Trafficking regulator of GLUT4 1

3

2

High-throughput

0.609

High

1370988

VSIG2
V-set and immunoglobulin domain-containing protein 2

3

8

High-throughput

0.609

High

1330724

SIGL1
SIGLEC family-like protein 1

3

7

High-throughput

0.604

High

683303

TNR5
Tumor necrosis factor receptor superfamily member 5

2

14

High-throughput

0.601

High

363673

EGFR
Epidermal growth factor receptor

2

11

High-throughput

0.594

High

346151

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

5

High-throughput

0.584

High

831177

CCNF
Cyclin-F

2

8

High-throughput

0.584

High

1135764

HAPR1
HUWE1-associated protein modifying stress responses 1

2

6

High-throughput

0.584

High

1149342

STIL
SCL-interrupting locus protein

2

1

High-throughput

0.584

High

1371000

ACE2
Angiotensin-converting enzyme 2

2

3

Small-scale

0.584

High

372756

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.571

High

479456

SRP19
Signal recognition particle 19 kDa protein

1

3

Small-scale

0.561

High

1315546

ULK2
Serine/threonine-protein kinase ULK2

1

1

Small-scale

0.561

High

1371036

NOSIP
Nitric oxide synthase-interacting protein

1

3

Small-scale

0.561

High

1272617

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

3

High-throughput

0.553

High

219991

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.536

High

291689

XRP2
Protein XRP2

1

4

High-throughput

0.536

High

328713

VAMP5
Vesicle-associated membrane protein 5

1

2

High-throughput

0.536

High

388265

GLPA
Glycophorin-A

1

4

High-throughput

0.536

High

410979

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

11

High-throughput

0.536

High

486599

TACD2
Tumor-associated calcium signal transducer 2

1

2

High-throughput

0.536

High

585814

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

4

High-throughput

0.536

High

665901

AKAP5
A-kinase anchor protein 5

1

1

High-throughput

0.536

High

690331

STOM
Stomatin

1

9

High-throughput

0.536

High

721046

CLIP1
CAP-Gly domain-containing linker protein 1

1

5

High-throughput

0.536

High

729387

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

7

High-throughput

0.536

High

849390

RANG
Ran-specific GTPase-activating protein

1

20

High-throughput

0.536

High

854707

RAGP1
Ran GTPase-activating protein 1

1

4

High-throughput

0.536

High

857521

NOTC1
Neurogenic locus notch homolog protein 1

1

3

High-throughput

0.536

High

867324

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

872605

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.536

High

890553

RBP2
E3 SUMO-protein ligase RanBP2

1

8

High-throughput

0.536

High

909646

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

9

High-throughput

0.536

High

932346

ARSF
Arylsulfatase F

1

2

High-throughput

0.536

High

965571

NTF2
Nuclear transport factor 2

1

7

High-throughput

0.536

High

1022925

EFNB1
Ephrin-B1

1

7

High-throughput

0.536

High

1033115

EWS
RNA-binding protein EWS

1

7

High-throughput

0.536

High

1096364

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

9

High-throughput

0.536

High

1106256

FOXE3
Forkhead box protein E3

1

1

High-throughput

0.536

High

1106366

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

6

Small-scale

0.536

High

1124511

MAP7
Ensconsin

1

11

High-throughput

0.536

High

1132569

FXYD3
FXYD domain-containing ion transport regulator 3

1

2

High-throughput

0.536

High

1290099

THOC4
THO complex subunit 4

1

5

High-throughput

0.536

High

1370986

MACIR
Macrophage immunometabolism regulator

1

1

High-throughput

0.536

High

1370991

QKI
KH domain-containing RNA-binding protein QKI

1

3

High-throughput

0.536

High

1370992

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.536

High

1370996

OVOL2
Transcription factor Ovo-like 2

1

20

High-throughput

0.536

High

1370998

KIFC1
Kinesin-like protein KIFC1

1

4

High-throughput

0.536

High

1371004

F234A
Protein FAM234A

1

5

High-throughput

0.536

High

1371027

NUP50
Nuclear pore complex protein Nup50

1

20

High-throughput

0.536

High

1371032

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

7

High-throughput

0.536

High

1371035

SIK3
Serine/threonine-protein kinase SIK3

1

1

High-throughput

0.536

High

1371042

SAR1B
Small COPII coat GTPase SAR1B

1

3

High-throughput

0.536

High

106402

APRIO
Alternative prion protein

2

6

High-throughput

0.533

High

1370994

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

20

Small-scale

0.527

High

156063

SOCS6
Suppressor of cytokine signaling 6

1

4

High-throughput

0.515

High

253778

UGDH
UDP-glucose 6-dehydrogenase

1

2

High-throughput

0.515

High

470327

NEP
Neprilysin

1

0

Small-scale

0.513

High

1370990

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

High-throughput

0.513

High

1371022

SUCO
SUN domain-containing ossification factor

1

0

High-throughput

0.513

High

1371026

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.513

High

916012

NUP98
Nuclear pore complex protein Nup98-Nup96

1

20

Small-scale

0.501

High

1287814

PABP2
Polyadenylate-binding protein 2

1

4

Small-scale

0.501

High

465600

IGF1R
Insulin-like growth factor 1 receptor

1

14

High-throughput

0.500

High

60735

F234B
Protein FAM234B

1

5

High-throughput

0.489

High

640248

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.489

High

1142125

P2RY6
P2Y purinoceptor 6

1

20

High-throughput

0.489

High

1249822

BTNL9
Butyrophilin-like protein 9

1

4

High-throughput

0.489

High

1272149

ARMX6
Protein ARMCX6

1

4

High-throughput

0.489

High

1291647

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

8

High-throughput

0.489

High

1325883

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

2

High-throughput

0.489

High

1349079

F174A
Membrane protein FAM174A

1

5

High-throughput

0.489

High

1371005

UN93B
Protein unc-93 homolog B1

1

7

High-throughput

0.489

High

1371008

PACC1
Proton-activated chloride channel

1

6

High-throughput

0.489

High

1371028

CAH14
Carbonic anhydrase 14

1

8

High-throughput

0.489

High

1371040

GPR45
Probable G-protein coupled receptor 45

1

11

High-throughput

0.489

High

1371041

NPTN
Neuroplastin

1

12

High-throughput

0.489

High

125557

LEG9
Galectin-9

1

5

High-throughput

0.479

High

176080

KDM6B
Lysine-specific demethylase 6B

1

3

Small-scale

0.479

High

260261

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

272367

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.479

High

291473

NU155
Nuclear pore complex protein Nup155

1

3

High-throughput

0.479

High

294118

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

315840

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.479

High

320746

UBXN7
UBX domain-containing protein 7

1

6

High-throughput

0.479

High

487605

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.479

High

520258

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

565440

ITA4
Integrin alpha-4

1

3

High-throughput

0.479

High

582603

PPAP
Prostatic acid phosphatase

1

1

High-throughput

0.479

High

589327

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

601795

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

Small-scale

0.479

High

606978

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.479

High

614717

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

10

High-throughput

0.479

High

658972

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

10

High-throughput

0.479

High

696123

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

705719

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

10

High-throughput

0.479

High

715708

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

Small-scale

0.479

High

731519

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.479

High

768811

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

799362

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.479

High

800020

COIL
Coilin

1

2

High-throughput

0.479

High

876960

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.479

High

895205

5HT6R
5-hydroxytryptamine receptor 6

1

7

Small-scale

0.479

High

904998

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

920160

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.479

High

941950

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.479

High

978641

RL23A
Large ribosomal subunit protein uL23

1

4

Small-scale

0.479

High

987841

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.479

High

990577

1433Z
14-3-3 protein zeta/delta

1

8

High-throughput

0.479

High

1004924

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.479

High

1040639

CREM
cAMP-responsive element modulator

1

2

Small-scale

0.479

High

1067576

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

1100941

G3BP1
Ras GTPase-activating protein-binding protein 1

1

7

High-throughput

0.479

High

1107993

SQSTM
Sequestosome-1

1

6

High-throughput

0.479

High

1155627

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

1163387

CAH9
Carbonic anhydrase 9

1

8

Small-scale

0.479

High

1164066

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

18

High-throughput

0.479

High

1178288

CL16A
Protein CLEC16A

1

3

High-throughput

0.479

High

1218620

OTU1
Ubiquitin thioesterase OTU1

1

3

High-throughput

0.479

High

1229606

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

1250580

DPPA3
Developmental pluripotency-associated protein 3

1

2

High-throughput

0.479

High

1254919

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1258359

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

1276588

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1280384

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

1286854

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.479

High

1288553

ZN598
E3 ubiquitin-protein ligase ZNF598

1

8

High-throughput

0.479

High

1312404

ASXL1
Polycomb group protein ASXL1

1

4

High-throughput

0.479

High

1314032

YAF2
YY1-associated factor 2

1

2

High-throughput

0.479

High

1324031

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.479

High

1332688

ZBT38
Zinc finger and BTB domain-containing protein 38

1

20

Small-scale

0.479

High

1333302

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1336808

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

10

High-throughput

0.479

High

1356851

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

12

High-throughput

0.479

High

1368029

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.479

High

1370983

SPDLY
Protein Spindly

1

3

High-throughput

0.479

High

1370987

DDRGK
DDRGK domain-containing protein 1

1

6

High-throughput

0.479

High

1370989

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

10

Small-scale

0.479

High

1370993

NECD
Necdin

1

7

Small-scale

0.479

High

1370995

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

1370997

DUS23
Dual specificity protein phosphatase 23

1

20

High-throughput

0.479

High

1371001

YTHD1
YTH domain-containing family protein 1

1

13

High-throughput

0.479

High

1371003

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

1371006

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.479

High

1371007

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.479

High

1371009

ECT2
Protein ECT2

1

8

High-throughput

0.479

High

1371011

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

1371012

ANLN
Anillin

1

9

High-throughput

0.479

High

1371013

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

1371018

TLS1
Splicing factor C9orf78

1

6

High-throughput

0.479

High

1371019

WWOX
WW domain-containing oxidoreductase

1

5

High-throughput

0.479

High

1371021

KIF17
Kinesin-like protein KIF17

1

2

Small-scale

0.479

High

1371025

ZRAN1
Ubiquitin thioesterase ZRANB1

1

16

High-throughput

0.479

High

1371030

TRI33
E3 ubiquitin-protein ligase TRIM33

1

12

High-throughput

0.479

High

1371031

HDAC5
Histone deacetylase 5

1

9

High-throughput

0.479

High

1371034

FND3A
Fibronectin type-III domain-containing protein 3A

1

6

High-throughput

0.479

High

1371037

ZN330
Zinc finger protein 330

1

4

High-throughput

0.479

High

1371038

YTHD2
YTH domain-containing family protein 2

1

13

High-throughput

0.479

High

1327112

FBXL6
F-box/LRR-repeat protein 6

1

5

High-throughput

0.470

High

1083472

MN1
Transcriptional activator MN1

1

0

Small-scale

0.458

High

1150145

TCEA2
Transcription elongation factor A protein 2

1

0

High-throughput

0.458

High

1197659

MIDN
Midnolin

1

0

High-throughput

0.458

High

1371024

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

1371014

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

166377

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

5

High-throughput

0.445

High

171544

S27A2
Long-chain fatty acid transport protein 2

1

20

High-throughput

0.445

High

344273

PTBP3
Polypyrimidine tract-binding protein 3

1

4

High-throughput

0.445

High

422782

A4
Amyloid-beta precursor protein

1

3

Small-scale

0.445

High

530173

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

564160

CFTR
Cystic fibrosis transmembrane conductance regulator

1

10

High-throughput

0.445

High

619884

VCAM1
Vascular cell adhesion protein 1

1

5

High-throughput

0.445

High

934955

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

1034509

TAGL
Transgelin

1

3

High-throughput

0.445

High

1241434

ZFP1
Zinc finger protein 1 homolog

1

20

High-throughput

0.445

High

378871

CD4
T-cell surface glycoprotein CD4

1

1

Small-scale

0.437

High

412386

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

643007

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.437

High

1229024

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.437

High

1249076

LMBRL
Protein LMBR1L

1

5

High-throughput

0.437

High

1313779

S15A3
Solute carrier family 15 member 3

1

5

High-throughput

0.437

High

1360908

CLC4D
C-type lectin domain family 4 member D

1

5

High-throughput

0.437

High

1370788

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

16

High-throughput

0.437

High

1371015

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.437

High

1371017

ATD3A
ATPase family AAA domain-containing protein 3A

1

8

High-throughput

0.437

High

1371029

CLC4E
C-type lectin domain family 4 member E

1

5

High-throughput

0.437

High

1371039

DJC15
DnaJ homolog subfamily C member 15

1

3

High-throughput

0.437

High

1371033

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

1093

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High

104197

F5H1C8
Solute carrier family 15 member 3

1

5

High-throughput

0.407

High

1240920

S27A4
Long-chain fatty acid transport protein 4

1

20

High-throughput

0.407

High

1243644

S27A1
Long-chain fatty acid transport protein 1

1

20

High-throughput

0.407

High

1292365

UN93A
Protein unc-93 homolog A

1

7

High-throughput

0.407

High

1335663

MOT11
Monocarboxylate transporter 11

1

6

High-throughput

0.407

High

1370982

S35B4
Nucleotide sugar transporter SLC35B4

1

5

High-throughput

0.407

High

1370985

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

2

High-throughput

0.407

High

1370999

TX101
Testis-expressed protein 101

1

3

High-throughput

0.407

High

1371010

SO1B3
Solute carrier organic anion transporter family member 1B3

1

6

High-throughput

0.407

High

1206209

T255A
Transmembrane protein 255A

1

0

High-throughput

0.279

Low

1212276

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.279

Low

1216580

PR14L
Protein PRR14L

1

0

High-throughput

0.279

Low

1252868

MBOA1
Membrane-bound glycerophospholipid O-acyltransferase 1

1

0

High-throughput

0.279

Low

993082

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.249

Low

1326856

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025