HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: PHF8 (Q9UPP1)
Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8)
Gene: PHF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	34316702
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007420 - brain development GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 1060
+	Hs
		1019385 TRI26_HUMAN (5-210): 1e-49: 175: 16.59		PHF8_HUMAN (1-1060): 0: 1403: 100.00
+	Hs
		718034 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Mm
		639474 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		KDM2B_MOUSE (88-968): 0: 585: 24.52
+	Hs
		718413 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Hs
		1108521 PCGF3_HUMAN (4-228): 4.43e-72: 225: 34.03		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Hs
		1311563 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		KDM2A_HUMAN (90-901): 0: 622: 25.09
+	Hs
		1245594 PCGF6_HUMAN (2-235): 2.13e-61: 201: 35.12		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Hs
		1245590 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Dm
		1367224 Q9VV77_DROME (3-229): 2.77e-68: 214: 36.80		JHD1_DROME (87-594): 0: 583: 33.27
+	Mm
		1158236 PCGF1_MOUSE (2-229): 5.71e-62: 199: 35.47		KDM2B_MOUSE (88-968): 0: 585: 24.52
+	Hs
		1197574 PCGF5_HUMAN (1-228): 9.27e-56: 183: 30.44		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Dm
		728809 PSC_DROME (3-240): 3.98e-55: 195: 41.91		JHD1_DROME (87-594): 0: 583: 33.27
+	Hs
		1245587 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Dm
		627171 SUZ2_DROME (1-227): 6e-48: 174: 32.76		JHD1_DROME (87-594): 0: 583: 33.27
+	Mm
		1158239 RING2_MOUSE (7-227): 5.77e-50: 171: 16.61		KDM2B_MOUSE (88-968): 0: 585: 24.52
+	Hs
		987996 RING1_HUMAN (7-115): 2.38e-30: 120: 25.46		KDM2B_HUMAN (75-968): 0: 601: 24.09
+	Mm
		193408 RING1_MOUSE (7-115): 1.2e-30: 121: 25.46		KDM2B_MOUSE (88-968): 0: 585: 24.52
+	Hs
		718151 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		DIDO1_HUMAN (41-92): 9.31e-11: 68.6: 46.43
+	Hs
		1304155 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		CXXC1_HUMAN (11-145): 9.34e-28: 122: 25.93
+	Hs
		1311529 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		DIDO1_HUMAN (41-92): 9.31e-11: 68.6: 46.43