HitPredict

Interactor 1: NOS2 (P35228)
Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Gene: NOS2

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11457725
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006954 - inflammatory response
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1153 Hs			1 192
+	Hs
		545231 NOS2_HUMAN (1-1153): 0: 1800: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Mm
		667784 NOS2_MOUSE (1-1150): 0: 1711: 80.78		RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00
+	Mm
		667792 NOS2_MOUSE (1-1150): 0: 1711: 80.78		RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67
+	Hs
		560186 NCPR_HUMAN (502-1128): 0: 749: 29.78		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		545195 NCPR_HUMAN (502-1128): 0: 749: 29.78		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		560181 NCPR_HUMAN (502-1128): 0: 749: 29.78		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		560188 NCPR_HUMAN (502-1128): 0: 749: 29.78		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		560182 NCPR_HUMAN (502-1128): 0: 749: 29.78		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		560184 NCPR_HUMAN (502-1128): 0: 749: 29.78		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436146 NCPR_HUMAN (502-1128): 0: 749: 29.78		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45