Protein: CD6
T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6]

Gene: CD6
Organism: Homo sapiens
Interactions: 159
UniProt ID: P30203

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0001771 - immunological synapse formation
GO:0001772 - immunological synapse
GO:0002250 - adaptive immune response
GO:0002438 - acute inflammatory response to antigenic stimulus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718368

CD6
T-cell differentiation antigen CD6

1

6

Small-scale

0.716

High

718396

CD166
CD166 antigen

4

4

Small-scale

0.708

High

438932

CD5
T-cell surface glycoprotein CD5

1

6

Small-scale

0.647

High

480720

LEG1
Galectin-1

1

5

Small-scale

0.536

High

609589

LEG3
Galectin-3

1

5

Small-scale

0.536

High

169968

AURKA
Aurora kinase A

1

1

High-throughput

0.536

High

275872

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

1

High-throughput

0.536

High

683966

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

5

High-throughput

0.536

High

714578

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

6

High-throughput

0.536

High

718373

GRK6
G protein-coupled receptor kinase 6

1

1

High-throughput

0.536

High

718375

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

3

High-throughput

0.536

High

718382

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.536

High

718383

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

3

High-throughput

0.536

High

718394

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

1

1

High-throughput

0.536

High

718405

PKHG4
Puratrophin-1

1

2

High-throughput

0.536

High

718410

TRI68
E3 ubiquitin-protein ligase TRIM68

1

1

High-throughput

0.536

High

718418

FRMD5
FERM domain-containing protein 5

1

8

High-throughput

0.536

High

718423

HOME1
Homer protein homolog 1

1

3

High-throughput

0.536

High

718432

VANG1
Vang-like protein 1

1

1

High-throughput

0.536

High

718433

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

3

High-throughput

0.536

High

718434

ARH40
Rho guanine nucleotide exchange factor 40

1

4

High-throughput

0.536

High

718437

SNX33
Sorting nexin-33

1

1

High-throughput

0.536

High

718438

RN138
E3 ubiquitin-protein ligase RNF138

1

6

High-throughput

0.536

High

718454

SNX18
Sorting nexin-18

1

1

High-throughput

0.536

High

718455

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

3

High-throughput

0.536

High

718462

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.536

High

718467

E41L5
Band 4.1-like protein 5

1

8

High-throughput

0.536

High

718473

HOME2
Homer protein homolog 2

1

3

High-throughput

0.536

High

718483

VANG2
Vang-like protein 2

1

1

High-throughput

0.536

High

718489

E41L3
Band 4.1-like protein 3

1

7

High-throughput

0.536

High

718374

GLYG
Glycogenin-1

1

0

High-throughput

0.518

High

718369

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

718384

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.513

High

718388

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.513

High

718393

PLD1
Phospholipase D1

1

0

High-throughput

0.513

High

718427

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.513

High

718430

CAMKV
CaM kinase-like vesicle-associated protein

1

0

High-throughput

0.513

High

718446

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

0

High-throughput

0.513

High

718450

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.513

High

718468

JPH1
Junctophilin-1

1

0

High-throughput

0.513

High

718472

LANC2
LanC-like protein 2

1

0

High-throughput

0.513

High

718480

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

134251

RPOM
DNA-directed RNA polymerase, mitochondrial

1

1

High-throughput

0.489

High

269744

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

1

High-throughput

0.489

High

271312

ZBED4
Zinc finger BED domain-containing protein 4

1

2

High-throughput

0.489

High

271930

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.489

High

285101

EED
Polycomb protein EED

1

2

High-throughput

0.489

High

320538

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

1

8

High-throughput

0.489

High

331716

MTMR5
Myotubularin-related protein 5

1

1

High-throughput

0.489

High

333946

SMC2
Structural maintenance of chromosomes protein 2

1

2

High-throughput

0.489

High

345155

ZMYM6
Zinc finger MYM-type protein 6

1

1

High-throughput

0.489

High

348063

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

4

High-throughput

0.489

High

600260

ZNF24
Zinc finger protein 24

1

1

High-throughput

0.489

High

604790

HXB9
Homeobox protein Hox-B9

1

2

High-throughput

0.489

High

617078

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

1

High-throughput

0.489

High

622766

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

5

High-throughput

0.489

High

625208

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.489

High

702876

DPOD1
DNA polymerase delta catalytic subunit

1

1

High-throughput

0.489

High

718372

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.489

High

718376

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.489

High

718378

FXR1
RNA-binding protein FXR1

1

7

High-throughput

0.489

High

718379

FXR2
RNA-binding protein FXR2

1

7

High-throughput

0.489

High

718381

RS26
Small ribosomal subunit protein eS26

1

1

High-throughput

0.489

High

718385

FOXK1
Forkhead box protein K1

1

3

High-throughput

0.489

High

718386

FOXK2
Forkhead box protein K2

1

3

High-throughput

0.489

High

718390

FMR1
Fragile X messenger ribonucleoprotein 1

1

7

High-throughput

0.489

High

718392

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.489

High

718395

CUL4B
Cullin-4B

1

7

High-throughput

0.489

High

718400

RRP5
Protein RRP5 homolog

1

1

High-throughput

0.489

High

718402

WDR43
WD repeat-containing protein 43

1

1

High-throughput

0.489

High

718403

RASA2
Ras GTPase-activating protein 2

1

1

High-throughput

0.489

High

718406

CEP78
Centrosomal protein of 78 kDa

1

1

High-throughput

0.489

High

718407

ZMYM1
Zinc finger MYM-type protein 1

1

1

High-throughput

0.489

High

718412

RETST
All-trans-retinol 13,14-reductase

1

1

High-throughput

0.489

High

718413

FIGL1
Fidgetin-like protein 1

1

2

High-throughput

0.489

High

718415

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.489

High

718421

KI18B
Kinesin-like protein KIF18B

1

1

High-throughput

0.489

High

718422

DZIP1
Cilium assembly protein DZIP1

1

6

High-throughput

0.489

High

718424

WDR75
WD repeat-containing protein 75

1

2

High-throughput

0.489

High

718425

DZI1L
Cilium assembly protein DZIP1L

1

8

High-throughput

0.489

High

718426

LRC47
Leucine-rich repeat-containing protein 47

1

1

High-throughput

0.489

High

718428

SRBD1
S1 RNA-binding domain-containing protein 1

1

1

High-throughput

0.489

High

718431

KBTB8
Kelch repeat and BTB domain-containing protein 8

1

2

High-throughput

0.489

High

718439

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

2

High-throughput

0.489

High

718440

BBX
HMG box transcription factor BBX

1

3

High-throughput

0.489

High

718444

RAD50
DNA repair protein RAD50

1

7

High-throughput

0.489

High

718445

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

1

High-throughput

0.489

High

718449

REXO5
RNA exonuclease 5

1

2

High-throughput

0.489

High

718451

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

1

2

High-throughput

0.489

High

718452

LENG8
Leukocyte receptor cluster member 8

1

1

High-throughput

0.489

High

718458

GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

1

1

High-throughput

0.489

High

718459

CRNL1
Crooked neck-like protein 1

1

1

High-throughput

0.489

High

718461

DDX47
Probable ATP-dependent RNA helicase DDX47

1

4

High-throughput

0.489

High

718465

ECT2
Protein ECT2

1

1

High-throughput

0.489

High

718469

MYNN
Myoneurin

1

1

High-throughput

0.489

High

718471

XPP1
Xaa-Pro aminopeptidase 1

1

1

High-throughput

0.489

High

718474

SMC4
Structural maintenance of chromosomes protein 4

1

3

High-throughput

0.489

High

718476

DDX56
Probable ATP-dependent RNA helicase DDX56

1

5

High-throughput

0.489

High

718477

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

2

High-throughput

0.489

High

718481

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.489

High

718482

TAOK2
Serine/threonine-protein kinase TAO2

1

2

High-throughput

0.489

High

718484

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

2

High-throughput

0.489

High

718487

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.489

High

718488

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.489

High

718492

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

7

High-throughput

0.489

High

140148

SDCB1
Syntenin-1

1

2

Small-scale

0.479

High

718391

LCP2
Lymphocyte cytosolic protein 2

1

1

High-throughput

0.457

High

75755

B3KW44
tRNA N(3)-cytidine methyltransferase

1

1

High-throughput

0.437

High

371264

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.437

High

718464

METL8
tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial

1

1

High-throughput

0.407

High

718398

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

0

High-throughput

0.282

High

51628

CBAR1
CBY1-interacting BAR domain-containing protein 1

1

0

High-throughput

0.279

Low

190830

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.279

Low

215979

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.279

Low

262023

NBN
Nibrin

1

0

High-throughput

0.279

Low

337686

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

339943

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

0

High-throughput

0.279

Low

667567

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.279

Low

718370

TF2H1
General transcription factor IIH subunit 1

1

0

High-throughput

0.279

Low

718371

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.279

Low

718377

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.279

Low

718380

SELB
Selenocysteine-specific elongation factor

1

0

High-throughput

0.279

Low

718387

AMPD2
AMP deaminase 2

1

0

High-throughput

0.279

Low

718389

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.279

Low

718397

TF2H2
General transcription factor IIH subunit 2

1

0

High-throughput

0.279

Low

718399

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.279

Low

718401

PSME4
Proteasome activator complex subunit 4

1

0

High-throughput

0.279

Low

718404

CTC1
CST complex subunit CTC1

1

0

High-throughput

0.279

Low

718408

DEP1A
DEP domain-containing protein 1A

1

0

High-throughput

0.279

Low

718409

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.279

Low

718411

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.279

Low

718414

ZN852
Zinc finger protein 852

1

0

High-throughput

0.279

Low

718416

APTX
Aprataxin

1

0

High-throughput

0.279

Low

718417

TRM1L
tRNA

1

0

High-throughput

0.279

Low

718419

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.279

Low

718420

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.279

Low

718429

TAC2N
Tandem C2 domains nuclear protein

1

0

High-throughput

0.279

Low

718435

TF3C2
General transcription factor 3C polypeptide 2

1

0

High-throughput

0.279

Low

718436

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.279

Low

718441

IP6K1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.279

Low

718442

ZN592
Zinc finger protein 592

1

0

High-throughput

0.279

Low

718443

TF2H4
General transcription factor IIH subunit 4

1

0

High-throughput

0.279

Low

718447

MCRS1
Microspherule protein 1

1

0

High-throughput

0.279

Low

718448

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.279

Low

718453

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

718456

PDD2L
Programmed cell death protein 2-like

1

0

High-throughput

0.279

Low

718457

TR61B
tRNA

1

0

High-throughput

0.279

Low

718460

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.279

Low

718463

STN1
CST complex subunit STN1

1

0

High-throughput

0.279

Low

718466

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.279

Low

718470

PRD10
PR domain zinc finger protein 10

1

0

High-throughput

0.279

Low

718475

TBCC1
TBCC domain-containing protein 1

1

0

High-throughput

0.279

Low

718478

DIP2B
Disco-interacting protein 2 homolog B

1

0

High-throughput

0.279

Low

718479

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.279

Low

718485

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.279

Low

718486

DUS12
Dual specificity protein phosphatase 12

1

0

High-throughput

0.279

Low

718490

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.279

Low

718491

HBS1L
HBS1-like protein

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025