Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: RADI (P35241)
Radixin
Gene: RDX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.691

The method score is based on:

Property Details
Experiments 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ERM_C~ERM_C, ERM_C~FERM_C, ERM_C~FERM_M, ERM_helical~FERM_N, FERM_C~FERM_C, FERM_C~FERM_M, FERM_C~FERM_N, FERM_M~FERM_M, FERM_M~FERM_N, FERM_N~FERM_N
Common GO terms GO:0003779 - actin binding
GO:0005886 - plasma membrane
GO:0005912 - adherens junction
GO:0008360 - regulation of cell shape
GO:0030027 - lamellipodium
and 7 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 595
Hs

1 583
+ Hs
+ Mm
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+ Hs
+ Hs
+ Hs
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+ Dm
+ Ce
+ Ce
+ Dm
+ Hs
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024