Protein: CBY1
Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)

Gene: CBY1
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q9Y3M2

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005802 - trans-Golgi network
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

51649

CBAR1
CBY1-interacting BAR domain-containing protein 1

4

2

High-throughput

0.704

High

990906

1433Z
14-3-3 protein zeta/delta

4

6

Small-scale

0.673

High

765146

CTNB1
Catenin beta-1

3

1

Small-scale

0.667

High

1315806

DZI1L
Cilium assembly protein DZIP1L

3

1

High-throughput

0.665

High

1145937

RBP1
RalA-binding protein 1

3

0

High-throughput

0.636

High

972167

1433E
14-3-3 protein epsilon

3

0

Small-scale

0.634

High

1397864

CFA53
Cilia- and flagella-associated protein 53

2

0

High-throughput

0.604

High

691571

1433T
14-3-3 protein theta

2

6

High-throughput

0.601

High

730386

1433B
14-3-3 protein beta/alpha

2

6

High-throughput

0.601

High

967058

1433G
14-3-3 protein gamma

2

6

High-throughput

0.601

High

1049937

1433F
14-3-3 protein eta

2

6

High-throughput

0.601

High

66528

RASFA
Ras association domain-containing protein 10

2

0

High-throughput

0.580

High

1204523

TP8L3
Tumor necrosis factor alpha-induced protein 8-like protein 3

2

0

High-throughput

0.580

High

1407504

TS101
Tumor susceptibility gene 101 protein

2

0

High-throughput

0.580

High

1430148

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

1348593

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.553

High

533801

CLUS
Clusterin

1

0

Small-scale

0.549

High

1244167

TT23L
Tetratricopeptide repeat protein 23-like

1

0

High-throughput

0.549

High

228931

CF410
Cilia- and flagella-associated protein 410

1

1

High-throughput

0.536

High

1124581

MAP7
Ensconsin

1

3

High-throughput

0.536

High

1135542

RHG19
Rho GTPase-activating protein 19

1

2

High-throughput

0.536

High

1270562

MARK2
Serine/threonine-protein kinase MARK2

1

1

High-throughput

0.536

High

1295151

DZIP1
Cilium assembly protein DZIP1

1

2

High-throughput

0.536

High

1025443

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.527

High

350757

NOE2
Noelin-2

1

0

High-throughput

0.513

High

549717

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

553103

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

659647

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

962662

RHOA
Transforming protein RhoA

1

0

High-throughput

0.513

High

977865

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

1032891

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

1211044

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.513

High

1327683

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.513

High

1381300

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.513

High

1384922

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.513

High

1418949

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.513

High

1431678

GAN
Gigaxonin

1

0

High-throughput

0.513

High

1451720

ABITM
Protein Abitram

1

0

High-throughput

0.513

High

1460695

DDX41
Probable ATP-dependent RNA helicase DDX41

1

0

High-throughput

0.513

High

1461520

ZN777
Zinc finger protein 777

1

0

High-throughput

0.513

High

1462765

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.513

High

1309968

MA7D3
MAP7 domain-containing protein 3

1

1

High-throughput

0.489

High

1452071

GDAP2
Ganglioside-induced differentiation-associated protein 2

1

1

High-throughput

0.489

High

1462602

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.486

High

281462

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.479

High

364074

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

521466

ARAF
Serine/threonine-protein kinase A-Raf

1

1

High-throughput

0.479

High

637984

NF1
Neurofibromin

1

2

High-throughput

0.479

High

719050

WEE1
Wee1-like protein kinase

1

1

High-throughput

0.479

High

719285

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719390

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

730980

1433S
14-3-3 protein sigma

1

6

Small-scale

0.479

High

828264

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.479

High

890913

TSC2
Tuberin

1

1

High-throughput

0.479

High

936494

AFAD
Afadin

1

3

High-throughput

0.479

High

941104

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

1025612

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

1057672

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.479

High

1060594

KLC1
Kinesin light chain 1

1

2

High-throughput

0.479

High

1065791

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

1

High-throughput

0.479

High

1090207

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

1

High-throughput

0.479

High

1092521

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.479

High

1121941

FA53B
Protein FAM53B

1

1

High-throughput

0.479

High

1152068

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

1

High-throughput

0.479

High

1198360

CRTC2
CREB-regulated transcription coactivator 2

1

2

High-throughput

0.479

High

1216111

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.479

High

1219100

DAB2P
Disabled homolog 2-interacting protein

1

2

High-throughput

0.479

High

1219646

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.479

High

1235047

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.479

High

1248124

CRTC3
CREB-regulated transcription coactivator 3

1

2

High-throughput

0.479

High

1248134

CRTC1
CREB-regulated transcription coactivator 1

1

2

High-throughput

0.479

High

1250838

RFIP1
Rab11 family-interacting protein 1

1

1

High-throughput

0.479

High

1251476

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.479

High

1272899

RFIP2
Rab11 family-interacting protein 2

1

1

High-throughput

0.479

High

1277721

MYCPP
C-myc promoter-binding protein

1

2

High-throughput

0.479

High

1309270

KSR1
Kinase suppressor of Ras 1

1

2

High-throughput

0.479

High

1316204

DCP1B
mRNA-decapping enzyme 1B

1

1

High-throughput

0.479

High

1349488

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1352626

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

1356784

HDAC7
Histone deacetylase 7

1

2

High-throughput

0.479

High

1401143

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

2

High-throughput

0.479

High

1407269

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

2

High-throughput

0.479

High

1410271

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1419849

OSBL6
Oxysterol-binding protein-related protein 6

1

1

High-throughput

0.479

High

1433838

OSBL3
Oxysterol-binding protein-related protein 3

1

1

High-throughput

0.479

High

1437691

PKHA5
Pleckstrin homology domain-containing family A member 5

1

2

High-throughput

0.479

High

1446496

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.479

High

1452556

FA53C
Protein FAM53C

1

1

High-throughput

0.479

High

1459759

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.479

High

1460601

NGAP
Ras GTPase-activating protein nGAP

1

2

High-throughput

0.479

High

1460947

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.479

High

1462723

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.479

High

1462750

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

1490931

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

2

High-throughput

0.479

High

1491254

STA13
StAR-related lipid transfer protein 13

1

2

High-throughput

0.479

High

1312919

DDIAS
DNA damage-induced apoptosis suppressor protein

1

0

Small-scale

0.460

High

159286

ABLM1
Actin-binding LIM protein 1

1

0

High-throughput

0.458

High

163198

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

219758

FOXO3
Forkhead box protein O3

1

0

High-throughput

0.458

High

252202

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

257075

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

0

High-throughput

0.458

High

269637

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

339123

NADK
NAD kinase

1

0

High-throughput

0.458

High

354814

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.458

High

869102

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

877049

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

964780

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.458

High

1065807

SPIR1
Protein spire homolog 1

1

0

High-throughput

0.458

High

1134091

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1204232

PDZ11
PDZ domain-containing protein 11

1

0

High-throughput

0.458

High

1216040

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.458

High

1245778

LARP1
La-related protein 1

1

0

High-throughput

0.458

High

1278234

CLAP1
CLIP-associating protein 1

1

0

High-throughput

0.458

High

1286567

PHLB2
Pleckstrin homology-like domain family B member 2

1

0

High-throughput

0.458

High

1287262

TBCD1
TBC1 domain family member 1

1

0

High-throughput

0.458

High

1322681

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

1325150

MILK1
MICAL-like protein 1

1

0

High-throughput

0.458

High

1339771

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1359469

LMO7
LIM domain only protein 7

1

0

High-throughput

0.458

High

1360424

SRS12
Serine/arginine-rich splicing factor 12

1

0

High-throughput

0.458

High

1370812

BAD
Bcl2-associated agonist of cell death

1

0

High-throughput

0.458

High

1383957

DACT3
Dapper homolog 3

1

0

High-throughput

0.458

High

1384062

AKTS1
Proline-rich AKT1 substrate 1

1

0

High-throughput

0.458

High

1390430

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

1400882

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1402233

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

1409809

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1410860

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1412896

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1419473

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

1448827

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1451988

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.458

High

1454078

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.458

High

1458381

PI4KB
Phosphatidylinositol 4-kinase beta

1

0

High-throughput

0.458

High

1461592

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1461674

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

1462707

BAIP2
BAR/IMD domain-containing adapter protein 2

1

0

High-throughput

0.458

High

176903

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.437

High

208763

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.437

High

230596

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.437

High

244197

KIF5C
Kinesin heavy chain isoform 5C

1

2

High-throughput

0.437

High

246194

KIF1B
Kinesin-like protein KIF1B

1

3

High-throughput

0.437

High

1129997

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.437

High

1187152

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.437

High

1229914

AN34A
Ankyrin repeat domain-containing protein 34A

1

1

High-throughput

0.437

High

1238323

REEP3
Receptor expression-enhancing protein 3

1

1

High-throughput

0.437

High

1242709

KLC3
Kinesin light chain 3

1

2

High-throughput

0.437

High

1257060

SYDE1
Rho GTPase-activating protein SYDE1

1

2

High-throughput

0.437

High

1352645

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

1

High-throughput

0.437

High

1357449

DEP1B
DEP domain-containing protein 1B

1

2

High-throughput

0.437

High

1434968

REEP4
Receptor expression-enhancing protein 4

1

1

High-throughput

0.437

High

1447286

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.437

High

1449438

KLC4
Kinesin light chain 4

1

2

High-throughput

0.437

High

333767

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

0

High-throughput

0.328

High

1398661

F161B
Protein FAM161B

2

0

High-throughput

0.316

High

1436728

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.316

High

1286988

NBPFB
NBPF family member NBPF11

1

0

Small-scale

0.299

High

282546

PAGE1
P antigen family member 1

1

0

High-throughput

0.279

Low

718490

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

1218322

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

0

High-throughput

0.279

Low

1231297

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.279

Low

1349002

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1398869

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

245296

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

0

High-throughput

0.249

Low

710587

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.249

Low

1233897

K0930
Uncharacterized protein KIAA0930

1

0

High-throughput

0.249

Low

1256811

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

0

High-throughput

0.249

Low

1275925

PBIR2
PABIR family member 2

1

0

High-throughput

0.249

Low

1293252

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

0

High-throughput

0.249

Low

1338131

NAV1
Neuron navigator 1

1

0

High-throughput

0.249

Low

1429337

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.249

Low

1438858

TANC2
Protein TANC2

1

0

High-throughput

0.249

Low

1454257

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

1454718

CING
Cingulin

1

0

High-throughput

0.249

Low

1462525

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.249

Low

1491255

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low

1491256

NUMBL
Numb-like protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025