HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34732716
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045597 - positive regulation of cell differentiation
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 317
+	Hs
		546975 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Hs
		640064 MOES_HUMAN (19-595): 5.97e-146: 435: 44.44		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00
+	Hs
		719400 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		SOX3_HUMAN (1-317): 1.78e-44: 159: 46.42
+	Hs
		719458 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		SOX4_HUMAN (9-289): 2.6e-33: 129: 26.69
+	Hs
		719464 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68
+	Hs
		996909 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68
+	Hs
		505670 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		CIC_HUMAN (3-272): 8.9e-33: 130: 22.26
+	Hs
		1301019 FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35		CIC_HUMAN (3-272): 8.9e-33: 130: 22.26
+	Hs
		1301010 E41L3_HUMAN (14-484): 8.79e-113: 363: 21.04		CIC_HUMAN (3-272): 8.9e-33: 130: 22.26
+	Hs
		204725 E41L2_HUMAN (11-519): 9e-113: 361: 19.70		CIC_HUMAN (3-272): 8.9e-33: 130: 22.26
+	Hs
		818555 FRM4A_HUMAN (30-315): 6.3e-29: 124: 28.67		SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00