HitPredict

Interactor 1: B3KSH4 (B3KSH4)
Huntingtin interacting protein 2, isoform CRA_a (cDNA FLJ36214 fis, clone THYMU2000672, highly similar to Ubiquitin-conjugating enzyme E2-25 kDa)
Gene: HIP2

Interactor 2: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.50	0.417

Property	Details
Experiments	19549727
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 282
+	Hs
		896333 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00
+	Hs
		919778 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00
+	Dm
		598818 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		SINA_DROME (25-281): 1.57e-109: 321: 81.32
+	Hs
		199105 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		SIAH2_HUMAN (28-282): 1.74e-103: 306: 83.20
+	Dm
		854588 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		SINAL_DROME (3-279): 8.36e-96: 287: 46.57
+	Hs
		896330 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		TRI50_HUMAN (34-235): 9.68e-46: 162: 19.15
+	Hs
		919773 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		TRI50_HUMAN (34-235): 9.68e-46: 162: 19.15
+	Dm
		854594 UBCD4_DROME (1-96): 7.84e-33: 114: 56.25		CYHR1_DROME (29-244): 1.56e-42: 152: 19.92
+	Hs
		896376 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		RNF41_HUMAN (25-152): 1.42e-32: 123: 17.65
+	Hs
		72165 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		RNF41_HUMAN (25-152): 1.42e-32: 123: 17.65
+	Hs
		896352 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		RN125_HUMAN (9-198): 3.5e-31: 117: 18.27
+	Hs
		72151 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		RN125_HUMAN (9-198): 3.5e-31: 117: 18.27
+	Hs
		484883 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		ZTRF1_HUMAN (2-228): 6.98e-28: 112: 20.59
+	Hs
		919821 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		RN125_HUMAN (9-198): 3.5e-31: 117: 18.27
+	Hs
		896402 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		RN114_HUMAN (22-123): 6.82e-18: 82.1: 26.85
+	Hs
		72172 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		RN114_HUMAN (22-123): 6.82e-18: 82.1: 26.85
+	Hs
		896320 UBE2K_HUMAN (1-97): 1.07e-33: 116: 100.00		TRAF7_HUMAN (39-129): 1.38e-11: 66.7: 23.36
+	Hs
		72140 B3KSH4_HUMAN (1-97): 7.05e-34: 113: 100.00		TRAF7_HUMAN (39-129): 1.38e-11: 66.7: 23.36
+	Hs
		919755 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		TRAF7_HUMAN (39-129): 1.38e-11: 66.7: 23.36
+	Hs
		919736 UB2D2_HUMAN (1-51): 4.95e-30: 105: 39.22		RN151_HUMAN (35-150): 2.56e-11: 64: 26.02