HitPredict

Interactor 1: MSX2 (P35548)
Homeobox protein MSX-2 (Homeobox protein Hox-8)
Gene: MSX2

Interactor 2: ATX1 (P54253)
Ataxin-1 (Spinocerebellar ataxia type 1 protein)
Gene: ATXN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	23275563
Identification Methods	two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 267 Hs			1 815
+	Hs
		234687 DLX3_HUMAN (31-258): 4.57e-39: 139: 27.71		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Hs
		641350 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Hs
		620136 PAX7_HUMAN (8-260): 3.22e-29: 116: 15.71		ATX1_HUMAN (1-815): 0: 1349: 100.00
+	Hs
		473475 TLX1_HUMAN (76-216): 1.68e-37: 136: 31.47		ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15
+	Hs
		473472 PAX6_HUMAN (11-263): 9.74e-32: 123: 16.61		ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15
+	Hs
		473469 PAX7_HUMAN (8-260): 3.22e-29: 116: 15.71		ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15
+	Hs
		213292 TLX2_HUMAN (137-216): 2.18e-11: 64.7: 45.00		ATX1L_HUMAN (1-815): 3.55e-108: 348: 27.15