HitPredict

Interactor 1: IRS1 (P35569)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: HDAC2 (P70288)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (YY1 transcription factor-binding protein)
Gene: HDAC2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15522123
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1233 Mm			1 488
+	Hs
		724558 IRS1_HUMAN (1-1233): 1.17e-137: 452: 86.75		HDAC2_HUMAN (1-488): 0: 707: 99.39
+	Hs
		151790 IRS4_HUMAN (11-1058): 1.2e-81: 294: 23.32		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		1038846 IRS2_HUMAN (13-1193): 2.42e-80: 291: 29.89		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		257678 ANR17_HUMAN (427-1233): 2.04e-29: 130: 10.01		HDAC2_HUMAN (1-488): 0: 707: 99.39
+	Hs
		1038560 ALMS1_HUMAN (273-1196): 2.05e-33: 143: 12.18		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		1270429 SP130_HUMAN (289-1062): 8.72e-14: 78.4: 8.79		HDAC2_HUMAN (1-488): 0: 707: 99.39
+	Hs
		257609 ANR17_HUMAN (427-1233): 2.04e-29: 130: 10.01		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		1038696 SP130_HUMAN (289-1062): 8.72e-14: 78.4: 8.79		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		110768 H7BXF5_HUMAN (310-1119): 1.16e-12: 75: 9.73		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Hs
		203227 SYNJ1_HUMAN (379-777): 1.58e-09: 64.9: 7.73		HDAC1_HUMAN (1-446): 0: 643: 89.24
+	Mm
		88461 D3Z656_MOUSE (403-983): 6.11e-14: 79.2: 9.37		HDAC4_MOUSE (1-377): 7.49e-132: 409: 23.89
+	Mm
		250690 ATX2_MOUSE (344-1170): 6.46e-12: 72.6: 8.71		HDAC4_MOUSE (1-377): 7.49e-132: 409: 23.89
+	Mm
		1157748 SYNJ1_MOUSE (535-1120): 6.57e-12: 72.5: 12.96		HDAC4_MOUSE (1-377): 7.49e-132: 409: 23.89
+	Mm
		1157688 ATX2L_MOUSE (528-1219): 2.42e-09: 64.2: 8.36		HDAC4_MOUSE (1-377): 7.49e-132: 409: 23.89
+	Hs
		1056969 MDC1_HUMAN (608-1230): 2.16e-09: 64.2: 8.99		HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40