Protein: GYS1
Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1)

Gene: GYS1
Organism: Homo sapiens
Interactions: 126
UniProt ID: P13807

Gene Ontology (top 5):
GO:0004373 - glycogen (starch) synthase activity
GO:0005536 - D-glucose binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005978 - glycogen biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533652

GLYG
Glycogenin-1

6

8

Small-scale

0.741

High

533661

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

5

6

High-throughput

0.723

High

180629

GLYG2
Glycogenin-2

4

8

High-throughput

0.706

High

533738

PPR3C
Protein phosphatase 1 regulatory subunit 3C

4

10

High-throughput

0.697

High

533655

GSK3B
Glycogen synthase kinase-3 beta

4

3

Small-scale

0.688

High

212352

AAKB2
5'-AMP-activated protein kinase subunit beta-2

3

3

High-throughput

0.675

High

307586

STBD1
Starch-binding domain-containing protein 1

3

1

High-throughput

0.667

High

533651

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

3

6

High-throughput

0.667

High

533664

GLGB
1,4-alpha-glucan-branching enzyme

2

1

High-throughput

0.628

High

204111

KLF4
Krueppel-like factor 4

2

1

High-throughput

0.606

High

533656

MEOX1
Homeobox protein MOX-1

2

2

High-throughput

0.606

High

533696

KAISO
Transcriptional regulator Kaiso

2

1

High-throughput

0.606

High

533692

NHLC1
E3 ubiquitin-protein ligase NHLRC1

2

1

Small-scale

0.595

High

533716

CSN5
COP9 signalosome complex subunit 5

2

0

High-throughput

0.585

High

235468

VINEX
Vinexin

2

0

High-throughput

0.580

High

533654

PCY1A
Choline-phosphate cytidylyltransferase A

2

0

High-throughput

0.580

High

533667

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

533682

BOREA
Borealin

2

0

High-throughput

0.580

High

533714

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.580

High

533728

KTBL1
KATNB1-like protein 1

2

0

High-throughput

0.580

High

226405

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

533643

HXB6
Homeobox protein Hox-B6

2

1

High-throughput

0.553

High

533648

HXC8
Homeobox protein Hox-C8

2

2

High-throughput

0.553

High

533671

KLF1
Krueppel-like factor 1

2

2

High-throughput

0.553

High

533693

ZN620
Zinc finger protein 620

2

1

High-throughput

0.553

High

533735

ZN212
Zinc finger protein 212

2

1

High-throughput

0.553

High

533668

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.549

High

533657

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

0

High-throughput

0.547

High

533673

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

0

High-throughput

0.547

High

506153

PYGB
Glycogen phosphorylase, brain form

1

2

High-throughput

0.536

High

533662

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

6

High-throughput

0.536

High

533669

MK07
Mitogen-activated protein kinase 7

1

2

High-throughput

0.536

High

533681

AAK1
AP2-associated protein kinase 1

1

2

High-throughput

0.536

High

533729

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.536

High

528458

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.528

High

533741

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.515

High

506509

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.513

High

533658

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

High-throughput

0.513

High

533672

CUL1
Cullin-1

1

0

High-throughput

0.513

High

533676

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.513

High

533677

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

0

High-throughput

0.513

High

533689

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.513

High

533706

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.513

High

533718

SGK3
Serine/threonine-protein kinase Sgk3

1

0

High-throughput

0.513

High

533719

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.513

High

533730

SLK
STE20-like serine/threonine-protein kinase

1

0

High-throughput

0.513

High

533737

CE164
Centrosomal protein of 164 kDa

1

0

High-throughput

0.513

High

533724

PASK
PAS domain-containing serine/threonine-protein kinase

1

1

Small-scale

0.501

High

533702

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

0

High-throughput

0.493

High

533720

OTUD5
OTU domain-containing protein 5

1

0

High-throughput

0.493

High

388019

AMYP
Pancreatic alpha-amylase

1

1

High-throughput

0.489

High

533680

PDK4
[Pyruvate dehydrogenase

1

1

High-throughput

0.489

High

533721

ZN514
Zinc finger protein 514

1

1

High-throughput

0.489

High

394037

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

125128

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

Small-scale

0.479

High

294321

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

533646

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

533659

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

High-throughput

0.479

High

533678

MK11
Mitogen-activated protein kinase 11

1

4

Small-scale

0.479

High

533679

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.479

High

533707

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

533726

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

1

6

High-throughput

0.479

High

533727

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

6

High-throughput

0.479

High

533731

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

533733

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

66258

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

162376

XPO1
Exportin-1

1

0

High-throughput

0.458

High

166665

CE290
Centrosomal protein of 290 kDa

1

0

High-throughput

0.458

High

302476

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

324731

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

0

High-throughput

0.458

High

377060

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

533645

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

High-throughput

0.458

High

533649

GRK5
G protein-coupled receptor kinase 5

1

0

High-throughput

0.458

High

533663

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.458

High

533666

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

533675

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

533688

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

533694

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

533698

LBN
Limbin

1

0

High-throughput

0.458

High

533701

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

533708

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

533710

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

533715

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

305940

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

6

High-throughput

0.445

High

533700

PPR3B
Protein phosphatase 1 regulatory subunit 3B

1

10

High-throughput

0.437

High

533712

ZFP41
Zinc finger protein 41 homolog

1

1

High-throughput

0.437

High

533713

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.437

High

200487

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

533674

BECN1
Beclin-1

1

0

High-throughput

0.426

High

533686

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.426

High

533703

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.426

High

533722

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

533725

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

533734

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

533739

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

533740

SHLB1
Endophilin-B1

1

0

High-throughput

0.426

High

401337

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

484804

AMY1B
Alpha-amylase 1B

1

1

High-throughput

0.407

High

533705

IHO1
Interactor of HORMAD1 protein 1

3

0

High-throughput

0.352

High

197657

CRX
Cone-rod homeobox protein

2

0

High-throughput

0.316

High

533644

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

0

High-throughput

0.316

High

533665

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

533683

ZN326
DBIRD complex subunit ZNF326

2

0

High-throughput

0.316

High

533684

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

533685

RBM48
RNA-binding protein 48

2

0

High-throughput

0.316

High

533687

CLVS2
Clavesin-2

2

0

High-throughput

0.316

High

533690

ZN774
Zinc finger protein 774

2

0

High-throughput

0.316

High

533691

ZN474
Zinc finger protein 474

2

0

High-throughput

0.316

High

533695

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

533699

F228A
Protein FAM228A

2

0

High-throughput

0.316

High

533711

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

533717

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

2

0

High-throughput

0.316

High

533723

PNMA5
Paraneoplastic antigen-like protein 5

2

0

High-throughput

0.316

High

533732

ZN552
Zinc finger protein 552

2

0

High-throughput

0.316

High

533736

PLAL2
Zinc finger protein PLAGL2

2

0

High-throughput

0.316

High

176663

SOX12
Transcription factor SOX-12

1

0

High-throughput

0.279

Low

533660

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.261

Low

533709

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

384195

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

533642

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

533647

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

533650

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

533653

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

533670

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

533704

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

533697

TLK2
Serine/threonine-protein kinase tousled-like 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024