Protein: FILA
Filaggrin

Gene: FILA, FLG
Organism: Homo sapiens
Interactions: 118
UniProt ID: P20930

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0018149 - peptide cross-linking

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

635578

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.638

High

291752

STK16
Serine/threonine-protein kinase 16

2

15

High-throughput

0.628

High

391564

FRIH
Ferritin heavy chain

2

3

High-throughput

0.628

High

456607

ANXA2
Annexin A2

1

13

High-throughput

0.618

High

635603

FILA2
Filaggrin-2

1

19

High-throughput

0.618

High

635583

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

1

High-throughput

0.611

High

635626

GMCL1
Germ cell-less protein-like 1

2

7

High-throughput

0.611

High

635575

UCP2
Dicarboxylate carrier SLC25A8

3

4

High-throughput

0.609

High

635594

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

12

High-throughput

0.609

High

635642

TNR19
Tumor necrosis factor receptor superfamily member 19

2

1

High-throughput

0.574

High

635566

CASPE
Caspase-14

2

4

Small-scale

0.571

High

635591

GPR18
N-arachidonyl glycine receptor

2

6

High-throughput

0.558

High

213392

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

3

High-throughput

0.552

High

635620

ESR2
Estrogen receptor beta

2

20

High-throughput

0.552

High

184265

NPHP1
Nephrocystin-1

1

1

High-throughput

0.536

High

282666

E2F6
Transcription factor E2F6

1

3

High-throughput

0.536

High

317134

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

7

High-throughput

0.536

High

552125

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.536

High

602732

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

622748

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

13

High-throughput

0.536

High

635563

CCNC
Cyclin-C

1

4

High-throughput

0.536

High

635574

AF17
Protein AF-17

1

3

High-throughput

0.536

High

635576

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

635577

DSCR6
Protein ripply3

1

5

High-throughput

0.536

High

635580

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.536

High

635586

CUL2
Cullin-2

1

20

High-throughput

0.536

High

635596

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.536

High

635602

LRC10
Leucine-rich repeat-containing protein 10

1

3

High-throughput

0.536

High

635608

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.536

High

635609

APTX
Aprataxin

1

2

High-throughput

0.536

High

635610

ZC3C1
Zinc finger C3HC-type protein 1

1

3

High-throughput

0.536

High

635638

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

4

High-throughput

0.536

High

635646

DTL
Denticleless protein homolog

1

4

High-throughput

0.536

High

635590

FLNC
Filamin-C

1

10

High-throughput

0.515

High

635597

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.515

High

635565

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

635637

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.513

High

635644

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.513

High

635653

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

5

Small-scale

0.501

High

292550

RENR
Renin receptor

1

3

High-throughput

0.489

High

325280

OR2A4
Olfactory receptor 2A4

1

5

High-throughput

0.489

High

635567

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.489

High

635572

PTSS1
Phosphatidylserine synthase 1

1

4

High-throughput

0.489

High

635592

I5P1
Inositol polyphosphate-5-phosphatase A

1

2

High-throughput

0.489

High

635599

CR021
UPF0711 protein C18orf21

1

4

High-throughput

0.489

High

635606

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.489

High

635612

S35F2
Solute carrier family 35 member F2

1

1

High-throughput

0.489

High

635614

FRMD1
FERM domain-containing protein 1

1

9

High-throughput

0.489

High

635616

FNDC5
Fibronectin type III domain-containing protein 5

1

8

High-throughput

0.489

High

635617

O13C3
Olfactory receptor 13C3

1

1

High-throughput

0.489

High

635622

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.489

High

635623

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.489

High

635624

ERP27
Endoplasmic reticulum resident protein 27

1

4

High-throughput

0.489

High

635627

SH23A
SH2 domain-containing protein 3A

1

12

High-throughput

0.489

High

635629

MMTA2
Multiple myeloma tumor-associated protein 2

1

3

High-throughput

0.489

High

635641

TSSP
Thymus-specific serine protease

1

1

High-throughput

0.489

High

635643

TB22B
TBC1 domain family member 22B

1

5

High-throughput

0.489

High

137957

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

6

High-throughput

0.479

High

141321

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

Small-scale

0.479

High

302372

RNF8
E3 ubiquitin-protein ligase RNF8

1

16

High-throughput

0.479

High

436793

K1C18
Keratin, type I cytoskeletal 18

1

5

High-throughput

0.479

High

484914

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

5

High-throughput

0.479

High

563186

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.479

High

623094

RO52
E3 ubiquitin-protein ligase TRIM21

1

8

High-throughput

0.479

High

634987

MAK
Serine/threonine-protein kinase MAK

1

13

High-throughput

0.479

High

635562

TBG1
Tubulin gamma-1 chain

1

4

High-throughput

0.479

High

635569

VHL
von Hippel-Lindau disease tumor suppressor

1

7

High-throughput

0.479

High

635573

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

635579

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

635581

KIF23
Kinesin-like protein KIF23

1

11

High-throughput

0.479

High

635582

DSG1
Desmoglein-1

1

5

High-throughput

0.479

High

635584

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

3

High-throughput

0.479

High

635587

PKP1
Plakophilin-1

1

6

High-throughput

0.479

High

635588

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.479

High

635593

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

14

High-throughput

0.479

High

635595

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

635600

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

635607

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

635621

FBXW7
F-box/WD repeat-containing protein 7

1

7

High-throughput

0.479

High

635630

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

16

High-throughput

0.479

High

635634

PRD14
PR domain zinc finger protein 14

1

5

Small-scale

0.479

High

635635

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

635636

TXNIP
Thioredoxin-interacting protein

1

13

Small-scale

0.479

High

635640

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

6

High-throughput

0.479

High

635647

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

635652

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

635564

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

635628

TMM79
Transmembrane protein 79

1

0

Small-scale

0.458

High

635589

KLF5
Krueppel-like factor 5

1

13

High-throughput

0.457

High

635598

DDR2
Discoidin domain-containing receptor 2

1

9

High-throughput

0.457

High

412929

CPNS1
Calpain small subunit 1

1

2

Small-scale

0.445

High

529065

TAU
Microtubule-associated protein tau

1

17

Small-scale

0.445

High

635568

BMI1
Polycomb complex protein BMI-1

1

19

High-throughput

0.445

High

635570

PI4KA
Phosphatidylinositol 4-kinase alpha

1

10

High-throughput

0.445

High

635585

STK4
Serine/threonine-protein kinase 4

1

7

High-throughput

0.445

High

635604

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

635632

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

15

High-throughput

0.445

High

635648

PADI1
Protein-arginine deiminase type-1

1

4

Small-scale

0.445

High

635649

PADI2
Protein-arginine deiminase type-2

1

4

Small-scale

0.445

High

635651

KLK5
Kallikrein-5

1

9

Small-scale

0.445

High

105321

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

584649

HIS3
Histatin-3

1

2

Small-scale

0.437

High

635601

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

10

High-throughput

0.437

High

635631

ACE2
Angiotensin-converting enzyme 2

1

4

High-throughput

0.437

High

635633

DDX24
ATP-dependent RNA helicase DDX24

1

7

High-throughput

0.437

High

635645

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

635571

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

635605

RNLS
Renalase

1

1

Small-scale

0.407

High

635611

Q8IXN4
non-specific serine/threonine protein kinase

1

13

High-throughput

0.407

High

635613

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.407

High

635615

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

7

High-throughput

0.407

High

635625

S39AD
Zinc transporter ZIP13

1

2

High-throughput

0.407

High

635650

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

66924

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.279

Low

194459

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.279

Low

635618

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.279

Low

635619

ZDH19
Palmitoyltransferase ZDHHC19

1

0

High-throughput

0.279

Low

635639

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025