Interactor 1: METK2 (P31153)
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)
Gene: MAT2A
Interactor 2: MAT2B (Q9NZL9)
Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase)
Gene: MAT2B
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.93 | 1.00 | 0.969 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26186194, 21516116, 28514442, 33961781, 25416956, 27548429, 12671891, 31839598 |
| Identification Methods | affinity chromatography technology, two hybrid, pull down, cross-linking study, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | RmlD_sub_bind~S-AdoMet_synt_C, RmlD_sub_bind~S-AdoMet_synt_M |
| Common GO terms | GO:0005829 - cytosol GO:0006556 - S-adenosylmethionine biosynthetic process GO:0006730 - one-carbon metabolic process GO:0048269 - methionine adenosyltransferase complex |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
