Protein: MAT2B
Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase)

Gene: MAT2B
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q9NZL9

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006556 - S-adenosylmethionine biosynthetic process
GO:0006730 - one-carbon metabolic process
GO:0019899 - enzyme binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

724813

METK2
S-adenosylmethionine synthase isoform type-2

8

1

Small-scale

0.969

High

1024321

METK1
S-adenosylmethionine synthase isoform type-1

4

1

High-throughput

0.892

High

138777

IMA4
Importin subunit alpha-4

3

2

High-throughput

0.675

High

1453417

MAT2B
Methionine adenosyltransferase 2 subunit beta

1

16

High-throughput

0.618

High

254494

PLPL9
85/88 kDa calcium-independent phospholipase A2

2

3

High-throughput

0.606

High

1144888

RABE1
Rab GTPase-binding effector protein 1

2

0

High-throughput

0.580

High

1398725

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

142628

IMA3
Importin subunit alpha-3

1

2

High-throughput

0.573

High

1143103

KPCD1
Serine/threonine-protein kinase D1

2

3

High-throughput

0.571

High

1213093

RHG21
Rho GTPase-activating protein 21

2

1

High-throughput

0.571

High

599635

STMN1
Stathmin

2

0

High-throughput

0.559

High

572251

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.549

High

770819

HRH1
Histamine H1 receptor

1

1

High-throughput

0.541

High

389546

FINC
Fibronectin

1

1

High-throughput

0.536

High

407900

SEMG1
Semenogelin-1

1

1

High-throughput

0.536

High

1036597

SEMG2
Semenogelin-2

1

1

High-throughput

0.536

High

838954

RHG25
Rho GTPase-activating protein 25

2

2

High-throughput

0.521

High

1310478

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

423340

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1349776

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

243153

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

347965

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

589895

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

696714

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

971205

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

1138703

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1387742

MBD6
Methyl-CpG-binding domain protein 6

1

1

High-throughput

0.479

High

1451291

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1453418

MBD5
Methyl-CpG-binding domain protein 5

1

2

High-throughput

0.479

High

1453419

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

260551

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

316089

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

831551

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

888357

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

1107285

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1140956

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1258397

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

160840

TOR1B
Torsin-1B

1

1

High-throughput

0.445

High

218876

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

769372

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1255864

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1434086

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1445792

DNJC4
DnaJ homolog subfamily C member 4

1

2

High-throughput

0.437

High

404934

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1453420

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

0

High-throughput

0.426

High

887277

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1408418

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

106757

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1313743

MILK2
MICAL-like protein 2

1

0

High-throughput

0.232

Low

1398004

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

1420740

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025