HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: SRSF9 (Q13242)
Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)
Gene: SRSF9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	29884807, 35271311, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 221
+	Hs
		992865 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95
+	Hs
		726769 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95
+	At
		1163070 CYP59_ARATH (205-524): 5.51e-32: 130: 13.45		SR30_ARATH (16-189): 8.72e-65: 203: 53.30
+	Hs
		1029024 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SRSF6_HUMAN (15-176): 1.67e-51: 171: 36.67
+	Mm
		1207139 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		SRSF9_MOUSE (2-221): 5.95e-54: 173: 98.64
+	Hs
		726792 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRSF5_HUMAN (12-176): 4.58e-54: 176: 35.20
+	Hs
		726793 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SRSF6_HUMAN (15-176): 1.67e-51: 171: 36.67
+	Hs
		726840 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SF3B4_HUMAN (1-211): 2.82e-49: 167: 15.32
+	At
		186862 CYP59_ARATH (205-524): 5.51e-32: 130: 13.45		SR34_ARATH (10-189): 1.6e-58: 188: 46.50
+	At
		1163069 CYP59_ARATH (205-524): 5.51e-32: 130: 13.45		Q9SPI1_ARATH (10-189): 7.15e-58: 186: 45.59
+	Hs
		516620 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP1_HUMAN (12-193): 1.8e-42: 153: 20.00
+	Hs
		967128 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SRSF1_HUMAN (1-183): 1.13e-57: 184: 69.95
+	Hs
		967148 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SRSF9_HUMAN (1-221): 1.6e-55: 178: 100.00
+	Hs
		516383 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP1_HUMAN (12-193): 1.8e-42: 153: 20.00
+	Hs
		967129 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SRSF4_HUMAN (15-169): 2.97e-47: 164: 39.52
+	At
		955324 CYP59_ARATH (205-524): 5.51e-32: 130: 13.45		SRS31_ARATH (16-220): 3.01e-46: 155: 27.18
+	Hs
		1031411 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		PABP4_HUMAN (5-104): 2.37e-21: 93.4: 19.80
+	Hs
		726795 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		PABP4_HUMAN (5-104): 2.37e-21: 93.4: 19.80
+	Mm
		1207135 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		RBM4_MOUSE (110-185): 1.67e-16: 78.8: 18.42
+	At
		1163064 CYP59_ARATH (205-524): 5.51e-32: 130: 13.45		RSZ33_ARATH (12-105): 3.23e-11: 63.2: 43.88