HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: DDX42 (Q86XP3)
ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)
Gene: DDX42

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25192599, 29884807, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 938
+	Hs
		1204682 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX42_HUMAN (1-938): 0: 739: 100.00
+	Hs
		1271148 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33
+	Hs
		726967 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33
+	Hs
		571537 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX5_HUMAN (197-734): 2.1e-147: 452: 35.37
+	Hs
		571333 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX5_HUMAN (197-734): 2.1e-147: 452: 35.37
+	Hs
		967316 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33
+	Hs
		1183340 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX46_HUMAN (8-863): 4.44e-137: 437: 29.71
+	Hs
		1271695 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33
+	Hs
		134145 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84
+	Hs
		571409 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDX5_HUMAN (197-734): 2.1e-147: 452: 35.37
+	Hs
		571634 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX5_HUMAN (197-734): 2.1e-147: 452: 35.37
+	Hs
		133903 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84
+	Hs
		571648 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		DDX5_HUMAN (197-734): 2.1e-147: 452: 35.37
+	Hs
		133984 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84
+	Hs
		134252 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84
+	Hs
		134018 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84
+	Hs
		133858 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84