Protein: URB1
Nucleolar pre-ribosomal-associated protein 1 (Unhealthy ribosome biogenesis protein 1)

Gene: URB1
Organism: Saccharomyces cerevisiae S288C
Interactions: 147
UniProt ID: P34241

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

758237

DBP6
ATP-dependent RNA helicase DBP6

7

2

Small-scale

0.748

High

758228

URB2
Nucleolar pre-ribosomal-associated protein 2

9

0

Small-scale

0.717

High

758264

NOP8
60S ribosome subunit biogenesis protein NOP8

8

0

Small-scale

0.714

High

758221

NOP2
25S rRNA

5

1

Small-scale

0.712

High

758258

RSA3
Ribosome assembly protein 3

7

0

Small-scale

0.712

High

758273

MAK21
Ribosome biogenesis protein MAK21

5

1

Small-scale

0.704

High

758278

NOP58
Nucleolar protein 58

5

2

Small-scale

0.699

High

758203

MAK5
ATP-dependent RNA helicase MAK5

4

2

Small-scale

0.691

High

758200

NOP4
Nucleolar protein 4

4

1

Small-scale

0.678

High

758208

SSF1
Ribosome biogenesis protein SSF1

5

0

High-throughput

0.676

High

758194

URB1
Nucleolar pre-ribosomal-associated protein 1

4

0

High-throughput

0.657

High

758254

ERB1
Ribosome biogenesis protein ERB1

3

0

Small-scale

0.642

High

758199

DBP7
ATP-dependent RNA helicase DBP7

3

3

Small-scale

0.640

High

738197

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

3

0

Small-scale

0.616

High

758234

PESC
Pescadillo homolog

3

0

Small-scale

0.613

High

758232

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

3

Small-scale

0.611

High

534095

MAK16
Protein MAK16

2

0

High-throughput

0.607

High

523533

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.601

High

682229

SPB4
ATP-dependent rRNA helicase SPB4

2

3

High-throughput

0.584

High

688993

RL16A
Large ribosomal subunit protein uL13A

2

1

Small-scale

0.584

High

758236

YG5X
Putative methyltransferase YGR283C

2

1

High-throughput

0.584

High

758248

HAS1
ATP-dependent RNA helicase HAS1

2

3

Small-scale

0.584

High

758259

DBP9
ATP-dependent RNA helicase DBP9

2

1

Small-scale

0.584

High

758276

NOP56
Nucleolar protein 56

2

2

Small-scale

0.584

High

758252

PUF6
Pumilio homology domain family member 6

2

0

Small-scale

0.576

High

700225

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

0

High-throughput

0.563

High

751368

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

Small-scale

0.559

High

758204

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

758207

CIC1
Proteasome-interacting protein CIC1

2

0

Small-scale

0.559

High

758209

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

Small-scale

0.559

High

758215

NOC2
Nucleolar complex protein 2

2

0

Small-scale

0.559

High

758226

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.559

High

758271

RRP6
Exosome complex exonuclease RRP6

2

0

High-throughput

0.559

High

758256

RRP5
rRNA biogenesis protein RRP5

2

0

Small-scale

0.547

High

364458

CDK1
Cyclin-dependent kinase 1

2

0

High-throughput

0.541

High

569960

RL3
Large ribosomal subunit protein uL3

2

1

Small-scale

0.533

High

544373

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.513

High

603038

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.513

High

721823

XPO1
Exportin-1

1

0

High-throughput

0.513

High

758246

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

758263

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

758266

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

677913

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.493

High

444762

SIR2
NAD-dependent histone deacetylase SIR2

1

1

High-throughput

0.479

High

585247

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

Small-scale

0.479

High

692550

NSR1
Nuclear localization sequence-binding protein

1

1

Small-scale

0.479

High

726912

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

746606

DRS1
ATP-dependent RNA helicase DRS1

1

1

Small-scale

0.479

High

750054

MRT4
Ribosome assembly factor MRT4

1

2

Small-scale

0.479

High

758195

RRP1
Ribosomal RNA-processing protein 1

1

1

Small-scale

0.479

High

758216

NUG1
Nuclear GTP-binding protein NUG1

1

1

Small-scale

0.479

High

758217

RIO2
Serine/threonine-protein kinase RIO2

1

1

High-throughput

0.479

High

758224

EMW1
Essential for maintenance of the cell wall protein 1

1

1

High-throughput

0.479

High

758231

VID30
GID complex subunit 1

1

1

High-throughput

0.479

High

758238

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.479

High

758242

NOP15
Ribosome biogenesis protein 15

1

1

Small-scale

0.479

High

758244

H3
Histone H3

1

1

High-throughput

0.479

High

758247

MLP1
Protein MLP1

1

1

High-throughput

0.479

High

758250

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

758255

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.479

High

758260

NOC4
Nucleolar complex protein 4

1

1

High-throughput

0.479

High

758267

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.479

High

758274

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

383285

RL28
Large ribosomal subunit protein uL15

1

0

Small-scale

0.458

High

403440

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.458

High

419684

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

434982

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

435882

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

478606

IF2B
Eukaryotic translation initiation factor 2 subunit beta

1

0

Small-scale

0.458

High

488939

SWI6
Regulatory protein SWI6

1

0

High-throughput

0.458

High

510959

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.458

High

594298

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.458

High

632550

DBP3
ATP-dependent RNA helicase DBP3

1

0

Small-scale

0.458

High

670551

SIS1
Protein SIS1

1

0

Small-scale

0.458

High

672866

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674529

RS2
Small ribosomal subunit protein uS5

1

0

Small-scale

0.458

High

676905

SRO9
RNA-binding protein SRO9

1

0

Small-scale

0.458

High

677183

SPB1
27S pre-rRNA

1

0

Small-scale

0.458

High

679546

CDC48
Cell division control protein 48

1

0

Small-scale

0.458

High

684677

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.458

High

706706

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

734923

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

735916

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

747786

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

758196

MPE1
Protein MPE1

1

0

High-throughput

0.458

High

758197

EBP2
rRNA-processing protein EBP2

1

0

Small-scale

0.458

High

758205

RS20
Small ribosomal subunit protein uS10

1

0

Small-scale

0.458

High

758206

RPN1
26S proteasome regulatory subunit RPN1

1

0

Small-scale

0.458

High

758212

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

Small-scale

0.458

High

758218

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

758219

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

758220

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

758223

T2FB
Transcription initiation factor IIF subunit beta

1

0

High-throughput

0.458

High

758225

KRI1
Protein KRI1

1

0

Small-scale

0.458

High

758230

NOL10
Ribosome biogenesis protein ENP2

1

0

Small-scale

0.458

High

758233

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

758235

PXR1
Protein PXR1

1

0

Small-scale

0.458

High

758241

NAT10
RNA cytidine acetyltransferase

1

0

Small-scale

0.458

High

758243

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

758249

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

758253

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

758257

HRQ1
ATP-dependent helicase HRQ1

1

0

Small-scale

0.458

High

758265

SGO1
Shugoshin

1

0

High-throughput

0.458

High

758268

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

Small-scale

0.458

High

758269

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

758275

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

758277

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.458

High

526332

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

741296

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

427212

RLA0
Large ribosomal subunit protein uL10

1

2

Small-scale

0.437

High

513479

RL1A
Large ribosomal subunit protein uL1A

1

2

High-throughput

0.437

High

577290

NSP1
Nucleoporin NSP1

1

1

Small-scale

0.437

High

628201

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

3

High-throughput

0.437

High

738461

NUP2
Nucleoporin NUP2

1

1

Small-scale

0.437

High

758261

IMH1
Golgin IMH1

1

1

High-throughput

0.437

High

758210

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.426

High

758239

LTO1
Protein LTO1

1

0

High-throughput

0.426

High

577088

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.407

High

752089

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

394424

EF1A
Elongation factor 1-alpha

2

0

Small-scale

0.298

High

410042

RL25
Large ribosomal subunit protein uL23

1

0

Small-scale

0.249

Low

427555

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.249

Low

433177

RL17A
Large ribosomal subunit protein uL22A

1

0

High-throughput

0.249

Low

502959

RS22A
Small ribosomal subunit protein uS8A

1

0

Small-scale

0.249

Low

503774

RL27A
Large ribosomal subunit protein eL27A

1

0

Small-scale

0.249

Low

558667

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

569748

RL30
Large ribosomal subunit protein eL30

1

0

Small-scale

0.249

Low

597425

EF3A
Elongation factor 3A

1

0

Small-scale

0.249

Low

734060

EF2
Elongation factor 2

1

0

Small-scale

0.249

Low

748323

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

758198

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

758201

RL32
Large ribosomal subunit protein eL32

1

0

Small-scale

0.249

Low

758202

SYG
Glycine--tRNA ligase 1, mitochondrial

1

0

High-throughput

0.249

Low

758211

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.249

Low

758213

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

758214

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

758222

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.249

Low

758229

GPN1
GPN-loop GTPase 1

1

0

Small-scale

0.249

Low

758245

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

758251

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

758262

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

758270

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

758272

GET3
ATPase GET3

1

0

High-throughput

0.249

Low

579150

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

758227

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

758240

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025