HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	27460707
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0051260 - protein homooligomerization GO:0140693 - molecular condensate scaffold activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 482
+	Hs
		1357450 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		1031497 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		516742 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		1030211 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		516494 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		867095 SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1073539 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		1049501 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		726839 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		726811 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		967196 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		967166 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Zm
		22429 A0A1D6I0G1_MAIZE (267-381): 6.88e-09: 60.4: 19.13		A0A1D6Q2L8_MAIZE (6-475): 6.16e-65: 218: 23.80
+	Sc
		376881 PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49		BRE5_YEAST (9-419): 2.98e-56: 197: 15.59
+	Hs
		1271149 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		726969 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		967317 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		1031413 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		516621 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63