Protein: EMC5
ER membrane protein complex subunit 5 (Killer toxin-resistance protein 27)

Gene: EMC5
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P40540

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0006644 - phospholipid metabolic process
GO:0015914 - phospholipid transport
GO:0034975 - protein folding in endoplasmic reticulum
GO:0045050 - protein insertion into ER membrane by stop-transfer membrane-anchor sequence

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

826157

EMC6
ER membrane protein complex subunit 6

2

0

Small-scale

0.759

High

677108

EMC1
ER membrane protein complex subunit 1

3

0

Small-scale

0.633

High

779976

EMC3
ER membrane protein complex subunit 3

3

0

Small-scale

0.633

High

826138

EMC2
ER membrane protein complex subunit 2

3

0

Small-scale

0.633

High

826141

EMC4
ER membrane protein complex subunit 4

3

0

Small-scale

0.633

High

812894

SOP4
Protein SOP4

3

0

Small-scale

0.630

High

796952

PHO88
SRP-independent targeting protein 3

2

0

High-throughput

0.588

High

796048

GPI18
GPI mannosyltransferase 2

2

0

High-throughput

0.587

High

826156

EMC10
Endoplasmic reticulum membrane protein complex subunit 10

2

0

Small-scale

0.559

High

826143

TMEDA
Endoplasmic reticulum vesicle protein 25

1

1

High-throughput

0.541

High

826153

ERP1
Protein ERP1

1

1

High-throughput

0.541

High

439528

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.518

High

528596

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.518

High

636318

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.518

High

826135

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.518

High

826136

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.518

High

826139

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.518

High

826142

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.518

High

826145

SHR3
Secretory component protein SHR3

1

0

High-throughput

0.518

High

826149

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

0

High-throughput

0.518

High

826154

ORM2
Protein ORM2

1

0

High-throughput

0.518

High

748430

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.458

High

826151

CUE4
CUE domain-containing protein CUE4

1

0

High-throughput

0.458

High

826159

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

727095

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

645111

EPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.438

High

798750

YSY6
Protein YSY6

1

0

High-throughput

0.438

High

752354

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.437

High

481646

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.407

High

524194

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.407

High

526896

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.407

High

545169

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

741740

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.407

High

571837

SNA3
Protein SNA3

2

0

High-throughput

0.317

High

826144

TOM5
Mitochondrial import receptor subunit TOM5

1

0

Small-scale

0.305

High

470540

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.282

High

515396

MTAL1
Mating-type protein ALPHA1

1

0

High-throughput

0.282

High

583749

DAL5
Allantoate permease

1

0

High-throughput

0.282

High

804024

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.282

High

806931

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

0

High-throughput

0.282

High

826137

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.282

High

826140

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.282

High

826146

PDR12
ATP-dependent permease PDR12

1

0

High-throughput

0.282

High

826147

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.282

High

826148

MUK1
Protein MUK1

1

0

High-throughput

0.282

High

826150

TVP15
Golgi apparatus membrane protein TVP15

1

0

High-throughput

0.282

High

826152

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.282

High

826155

ARO10
Transaminated amino acid decarboxylase

1

0

High-throughput

0.282

High

826158

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.282

High

679776

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

579541

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

626769

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

676069

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low

816246

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025