HitPredict

Interactor 1: HNF1B (P35680)
Hepatocyte nuclear factor 1-beta (HNF-1-beta) (HNF-1B) (Homeoprotein LFB3) (Transcription factor 2) (TCF-2) (Variant hepatic nuclear factor 1) (vHNF1)
Gene: HNF1B

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 557 Hs			1 197
+	Hs
		727504 HNF1B_HUMAN (1-557): 6.73e-147: 436: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		727505 HNF1B_HUMAN (1-557): 6.73e-147: 436: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		595923 HNF1A_HUMAN (1-551): 2.16e-85: 279: 53.21		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		620144 PAX7_HUMAN (84-479): 2.24e-58: 204: 15.58		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Mm
		623700 PAX3_MOUSE (84-483): 1.11e-58: 204: 16.20		TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59
+	Hs
		641379 PAX6_HUMAN (83-460): 3.74e-59: 204: 15.54		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		620142 PAX7_HUMAN (84-479): 2.24e-58: 204: 15.58		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		641377 PAX6_HUMAN (83-460): 3.74e-59: 204: 15.54		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		620143 PAX7_HUMAN (84-479): 2.24e-58: 204: 15.58		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		641378 PAX6_HUMAN (83-460): 3.74e-59: 204: 15.54		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		620146 PAX7_HUMAN (84-479): 2.24e-58: 204: 15.58		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		641385 PAX6_HUMAN (83-460): 3.74e-59: 204: 15.54		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		971652 PAX5_HUMAN (83-401): 2.61e-40: 152: 11.68		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980927 PAX8_HUMAN (83-439): 4.26e-37: 144: 9.43		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980588 PAX8_HUMAN (83-439): 4.26e-37: 144: 9.43		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		973842 PAX2_HUMAN (83-401): 6.33e-36: 141: 9.47		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980733 PAX8_HUMAN (83-439): 4.26e-37: 144: 9.43		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		973843 PAX2_HUMAN (83-401): 6.33e-36: 141: 9.47		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		988754 PAX8_HUMAN (83-439): 4.26e-37: 144: 9.43		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		973846 PAX2_HUMAN (83-401): 6.33e-36: 141: 9.47		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00