Protein: ZEP1
Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1)

Gene: ZEP1, HIVEP1
Organism: Homo sapiens
Interactions: 186
UniProt ID: P15822

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

586259

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.754

High

586358

FBW1A
F-box/WD repeat-containing protein 1A

6

6

Small-scale

0.733

High

586354

FBW1B
F-box/WD repeat-containing protein 11

4

6

High-throughput

0.699

High

586301

MK14
Mitogen-activated protein kinase 14

1

3

High-throughput

0.698

High

586290

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

3

High-throughput

0.691

High

586260

1433G
14-3-3 protein gamma

4

18

High-throughput

0.691

High

586279

1433F
14-3-3 protein eta

4

18

High-throughput

0.691

High

586232

1433B
14-3-3 protein beta/alpha

4

18

High-throughput

0.687

High

586257

ATX1
Ataxin-1

3

1

High-throughput

0.678

High

586263

1433Z
14-3-3 protein zeta/delta

3

18

High-throughput

0.662

High

586251

CLK1
Dual specificity protein kinase CLK1

1

6

High-throughput

0.647

High

586266

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.647

High

586215

ZEP1
Zinc finger protein 40

1

15

High-throughput

0.621

High

586245

MK08
Mitogen-activated protein kinase 8

1

3

High-throughput

0.621

High

586272

SP4
Transcription factor Sp4

1

20

High-throughput

0.621

High

586296

VEZF1
Vascular endothelial zinc finger 1

1

13

High-throughput

0.621

High

586300

ZFHX3
Zinc finger homeobox protein 3

1

7

High-throughput

0.621

High

216876

KLF4
Krueppel-like factor 4

1

20

High-throughput

0.618

High

339645

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.618

High

538365

EGR2
E3 SUMO-protein ligase EGR2

1

17

High-throughput

0.618

High

586224

TYY1
Transcriptional repressor protein YY1

1

20

High-throughput

0.618

High

586248

CDK8
Cyclin-dependent kinase 8

1

2

High-throughput

0.618

High

586286

KLF10
Krueppel-like factor 10

1

20

High-throughput

0.618

High

586293

KLF9
Krueppel-like factor 9

1

20

High-throughput

0.618

High

586294

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.618

High

586324

SP7
Transcription factor Sp7

1

20

High-throughput

0.618

High

586344

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.618

High

586353

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.618

High

586359

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

185406

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

2

2

High-throughput

0.614

High

586268

SMAD3
Mothers against decapentaplegic homolog 3

2

6

High-throughput

0.595

High

586274

HEN1
Helix-loop-helix protein 1

2

7

High-throughput

0.586

High

586295

NFYC
Nuclear transcription factor Y subunit gamma

2

1

High-throughput

0.586

High

142817

NFIB
Nuclear factor 1 B-type

2

13

High-throughput

0.584

High

473767

NFIC
Nuclear factor 1 C-type

2

15

High-throughput

0.584

High

586283

NFIA
Nuclear factor 1 A-type

2

16

High-throughput

0.584

High

586298

NFIX
Nuclear factor 1 X-type

2

17

High-throughput

0.584

High

505512

ATX1L
Ataxin-1-like

2

1

High-throughput

0.584

High

154933

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.559

High

139680

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

2

High-throughput

0.552

High

586253

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

586254

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.541

High

586262

RAB1A
Ras-related protein Rab-1A

1

1

High-throughput

0.541

High

586218

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.536

High

586255

STA5B
Signal transducer and activator of transcription 5B

1

1

High-throughput

0.536

High

586261

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.536

High

586264

SKP1
S-phase kinase-associated protein 1

1

3

High-throughput

0.536

High

586287

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

586291

IRF5
Interferon regulatory factor 5

1

1

High-throughput

0.536

High

586325

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

2

High-throughput

0.536

High

446606

NPM
Nucleophosmin

1

9

High-throughput

0.515

High

486917

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.515

High

586236

MYH9
Myosin-9

1

1

High-throughput

0.515

High

586331

H2B1H
Histone H2B type 1-H

1

16

High-throughput

0.515

High

361101

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

586309

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

586348

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

586316

APTX
Aprataxin

1

1

High-throughput

0.508

High

586333

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

6

Small-scale

0.506

High

586350

NLGN3
Neuroligin-3

1

1

High-throughput

0.494

High

47954

RBM47
RNA-binding protein 47

1

3

High-throughput

0.481

High

140135

SDCB1
Syntenin-1

1

1

High-throughput

0.481

High

155903

SOCS3
Suppressor of cytokine signaling 3

1

6

High-throughput

0.481

High

296956

CCNK
Cyclin-K

1

3

High-throughput

0.481

High

530985

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

2

High-throughput

0.481

High

576152

PO2F1
POU domain, class 2, transcription factor 1

1

7

High-throughput

0.481

High

586216

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.481

High

586231

DNJA1
DnaJ homolog subfamily A member 1

1

5

High-throughput

0.481

High

586233

OTX1
Homeobox protein OTX1

1

11

High-throughput

0.481

High

586240

BRCA1
Breast cancer type 1 susceptibility protein

1

15

High-throughput

0.481

High

586242

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.481

High

586267

PO6F2
POU domain, class 6, transcription factor 2

1

6

High-throughput

0.481

High

586297

ELOA1
Elongin-A

1

2

High-throughput

0.481

High

586302

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.481

High

586307

QRIC1
Transcriptional regulator QRICH1

1

4

High-throughput

0.481

High

586317

POGZ
Pogo transposable element with ZNF domain

1

5

High-throughput

0.481

High

586318

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

1

2

High-throughput

0.481

High

586327

CBP
CREB-binding protein

1

16

Small-scale

0.481

High

586335

SH3K1
SH3 domain-containing kinase-binding protein 1

1

6

High-throughput

0.481

High

586360

MAGD1
Melanoma-associated antigen D1

1

4

High-throughput

0.481

High

130366

SPT5H
Transcription elongation factor SPT5

1

4

High-throughput

0.479

High

181487

TBXT
T-box transcription factor T

1

1

High-throughput

0.479

High

224936

TLX3
T-cell leukemia homeobox protein 3

1

11

High-throughput

0.479

High

246417

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.479

High

359915

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.479

High

370541

FOS
Protein c-Fos

1

8

High-throughput

0.479

High

403795

GCR
Glucocorticoid receptor

1

11

High-throughput

0.479

High

413128

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

507495

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.479

High

519326

MYB
Transcriptional activator Myb

1

1

High-throughput

0.479

High

519714

ANDR
Androgen receptor

1

11

High-throughput

0.479

High

540799

ERG
Transcriptional regulator ERG

1

6

High-throughput

0.479

High

549275

SRF
Serum response factor

1

2

High-throughput

0.479

High

577396

ETS1
Protein C-ets-1

1

6

High-throughput

0.479

High

581615

MYOD1
Myoblast determination protein 1

1

4

High-throughput

0.479

High

586217

TAL1
T-cell acute lymphocytic leukemia protein 1

1

7

High-throughput

0.479

High

586221

PAX7
Paired box protein Pax-7

1

13

High-throughput

0.479

High

586222

GATA2
Endothelial transcription factor GATA-2

1

4

High-throughput

0.479

High

586223

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

4

High-throughput

0.479

High

586225

PAX6
Paired box protein Pax-6

1

10

High-throughput

0.479

High

586227

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

586229

RABP2
Cellular retinoic acid-binding protein 2

1

2

High-throughput

0.479

High

586230

TLX1
T-cell leukemia homeobox protein 1

1

9

High-throughput

0.479

High

586234

ELF1
ETS-related transcription factor Elf-1

1

7

High-throughput

0.479

High

586237

HNF1B
Hepatocyte nuclear factor 1-beta

1

12

High-throughput

0.479

High

586239

PPARG
Peroxisome proliferator-activated receptor gamma

1

10

High-throughput

0.479

High

586241

COIL
Coilin

1

3

High-throughput

0.479

High

586243

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

High-throughput

0.479

High

586244

ELK3
ETS domain-containing protein Elk-3

1

7

High-throughput

0.479

High

586246

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

586247

LHX1
LIM/homeobox protein Lhx1

1

16

High-throughput

0.479

High

586249

CENPA
Histone H3-like centromeric protein A

1

10

High-throughput

0.479

High

586250

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.479

High

586252

LHX2
LIM/homeobox protein Lhx2

1

18

High-throughput

0.479

High

586258

GSC
Homeobox protein goosecoid

1

12

High-throughput

0.479

High

586265

H31
Histone H3.1

1

10

High-throughput

0.479

High

586269

H33
Histone H3.3

1

10

High-throughput

0.479

High

586273

IRF8
Interferon regulatory factor 8

1

1

High-throughput

0.479

High

586276

PAX2
Paired box protein Pax-2

1

10

High-throughput

0.479

High

586277

ERCC6
DNA excision repair protein ERCC-6

1

13

High-throughput

0.479

High

586278

TLE3
Transducin-like enhancer protein 3

1

11

High-throughput

0.479

High

586280

HME1
Homeobox protein engrailed-1

1

4

High-throughput

0.479

High

586281

PAX8
Paired box protein Pax-8

1

10

High-throughput

0.479

High

586284

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.479

High

586288

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

586289

HDAC1
Histone deacetylase 1

1

14

High-throughput

0.479

High

586299

ELF2
ETS-related transcription factor Elf-2

1

6

High-throughput

0.479

High

586303

RBBP7
Histone-binding protein RBBP7

1

8

High-throughput

0.479

High

586304

TBR1
T-box brain protein 1

1

1

High-throughput

0.479

High

586313

FBX38
F-box only protein 38

1

1

High-throughput

0.479

High

586319

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

586322

NUP43
Nucleoporin Nup43

1

8

High-throughput

0.479

High

586332

LHX4
LIM/homeobox protein Lhx4

1

20

High-throughput

0.479

High

586336

PF21A
PHD finger protein 21A

1

20

High-throughput

0.479

High

586339

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.479

High

586342

FEV
Protein FEV

1

5

High-throughput

0.479

High

586351

LHX3
LIM/homeobox protein Lhx3

1

19

High-throughput

0.479

High

586355

RCOR1
REST corepressor 1

1

8

High-throughput

0.479

High

586356

LHX6
LIM/homeobox protein Lhx6

1

17

High-throughput

0.479

High

586361

ETV7
Transcription factor ETV7

1

6

High-throughput

0.479

High

421179

ALDOB
Fructose-bisphosphate aldolase B

1

0

High-throughput

0.460

High

586235

HPPD
4-hydroxyphenylpyruvate dioxygenase

1

0

High-throughput

0.460

High

586256

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

0

High-throughput

0.460

High

586285

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

0

High-throughput

0.460

High

586292

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

0

High-throughput

0.460

High

586305

NRF1
Nuclear respiratory factor 1

1

0

High-throughput

0.460

High

586306

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.460

High

586320

BANP
Protein BANP

1

0

High-throughput

0.460

High

586330

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.460

High

586334

TET5B
Terminal nucleotidyltransferase 5B

1

0

High-throughput

0.460

High

586341

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.460

High

586343

MIEN1
Migration and invasion enhancer 1

1

0

High-throughput

0.460

High

586347

RN186
E3 ubiquitin-protein ligase RNF186

1

0

High-throughput

0.460

High

586352

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.460

High

378470

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

586220

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

586228

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

586308

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

586326

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

586345

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

586346

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

586349

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

586357

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

586226

1433T
14-3-3 protein theta

1

18

High-throughput

0.445

High

586311

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.445

High

586314

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.445

High

329821

SNX4
Sorting nexin-4

1

1

High-throughput

0.439

High

519590

LYAG
Lysosomal alpha-glucosidase

1

1

High-throughput

0.439

High

586321

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.439

High

586328

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.438

High

586282

GOGA2
Golgin subfamily A member 2

1

12

High-throughput

0.437

High

586312

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

586238

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.426

High

586219

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

1

High-throughput

0.407

High

586315

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.279

Low

455899

ASGR1
Asialoglycoprotein receptor 1

1

0

High-throughput

0.251

Low

586270

PR20A
Proline-rich protein 20A

1

0

High-throughput

0.251

Low

586271

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

0

High-throughput

0.251

Low

586275

NUCB1
Nucleobindin-1

1

0

High-throughput

0.251

Low

586310

VCF2
Protein VCF2

1

0

High-throughput

0.251

Low

586323

GSDMB
Gasdermin-B

1

0

High-throughput

0.251

Low

586329

NINJ1
Ninjurin-1

1

0

High-throughput

0.251

Low

586337

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.251

Low

586338

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.251

Low

586340

T176A
Transmembrane protein 176A

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025