HitPredict

Interactor 1: SOX5 (P35711)
Transcription factor SOX-5
Gene: SOX5

Interactor 2: ARI5A (Q03989)
AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1)
Gene: ARID5A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	25416956, 21516116
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0002062 - chondrocyte differentiation GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 763 Hs			1 594
+	Hs
		727753 SOX5_HUMAN (1-763): 0: 611: 100.00		ARI4B_HUMAN (60-246): 1.2e-32: 136: 21.18
+	Hs
		727876 SOX6_HUMAN (14-763): 6.99e-144: 444: 56.44		ARI4B_HUMAN (60-246): 1.2e-32: 136: 21.18
+	Mm
		818735 SOX2_MOUSE (522-642): 3.82e-36: 140: 38.02		ARI5B_MOUSE (2-387): 1.89e-75: 262: 34.62
+	Hs
		818057 SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10		ARI5B_HUMAN (2-387): 1.11e-70: 249: 31.19
+	Hs
		818820 SOX9_HUMAN (463-700): 7.73e-45: 170: 26.86		ARI1B_HUMAN (1-324): 4.28e-56: 207: 15.49
+	Mm
		818732 SOX2_MOUSE (522-642): 3.82e-36: 140: 38.02		KDM5B_MOUSE (21-319): 3.88e-59: 215: 16.93
+	Hs
		818269 SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10		ARI1B_HUMAN (1-324): 4.28e-56: 207: 15.49
+	Hs
		818838 SOX9_HUMAN (463-700): 7.73e-45: 170: 26.86		ARI3A_HUMAN (4-233): 5.38e-43: 164: 18.03
+	Hs
		146178 SOX9_HUMAN (463-700): 7.73e-45: 170: 26.86		ARI1A_HUMAN (1-338): 6.15e-38: 152: 13.04
+	Hs
		818818 SOX9_HUMAN (463-700): 7.73e-45: 170: 26.86		ARI3B_HUMAN (2-287): 1.14e-38: 151: 13.45
+	Hs
		818808 SOX9_HUMAN (463-700): 7.73e-45: 170: 26.86		ARI4B_HUMAN (60-246): 1.2e-32: 136: 21.18
+	Hs
		818394 SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10		ARI3A_HUMAN (4-233): 5.38e-43: 164: 18.03
+	Hs
		818810 SOX9_HUMAN (463-700): 7.73e-45: 170: 26.86		ARID2_HUMAN (52-162): 3.76e-31: 131: 29.46
+	Hs
		146177 SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10		ARI1A_HUMAN (1-338): 6.15e-38: 152: 13.04
+	Hs
		818223 SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10		ARI3B_HUMAN (2-287): 1.14e-38: 151: 13.45
+	Mm
		57760 SOX2_MOUSE (522-642): 3.82e-36: 140: 38.02		ARI1A_MOUSE (1-333): 8.13e-37: 149: 14.70
+	Hs
		666502 CIC_HUMAN (305-752): 1.22e-35: 147: 15.96		ARI4A_HUMAN (25-221): 5.8e-34: 140: 22.84
+	Hs
		1117689 CIC_HUMAN (305-752): 1.22e-35: 147: 15.96		ARI4B_HUMAN (60-246): 1.2e-32: 136: 21.18
+	Hs
		818112 SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10		ARI4B_HUMAN (60-246): 1.2e-32: 136: 21.18
+	Hs
		818146 SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10		ARID2_HUMAN (52-162): 3.76e-31: 131: 29.46