HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: EFNA4 (P52798)
Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)
Gene: EFNA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	23686814
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 201
+	Hs
		380584 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		380559 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59
+	Hs
		856412 K2C73_HUMAN (1-598): 8.9e-92: 296: 51.00		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		380583 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		856362 KRT85_HUMAN (5-491): 4.47e-87: 282: 45.59		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		856361 KRT83_HUMAN (83-491): 2.11e-86: 280: 49.02		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		531544 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		380454 K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		821645 K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		359474 K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22		EFNA4_HUMAN (1-185): 1.68e-86: 255: 100.00
+	Hs
		531533 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59
+	Hs
		380444 K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59
+	Hs
		595981 K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59
+	Hs
		359465 K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59
+	Hs
		531543 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		380453 K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		821644 K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		856320 K2C71_HUMAN (1-570): 6.15e-82: 269: 51.23		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		359473 K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22		EFNA3_HUMAN (21-169): 8.45e-61: 191: 42.50
+	Hs
		595979 K22E_HUMAN (1-517): 4.22e-68: 235: 100.00		EFNA1_HUMAN (11-162): 3.84e-69: 211: 43.59