HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: K1C39 (Q6A163)
Keratin, type I cytoskeletal 39 (Cytokeratin-39) (CK-39) (Keratin-39) (K39) (Type I hair keratin Ka35)
Gene: KRT39

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	36949045
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 491
+	Hs
		409071 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KT33B_HUMAN (49-454): 1.44e-149: 434: 57.18
+	Hs
		359290 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C14_HUMAN (94-480): 5.8e-147: 430: 45.74
+	Hs
		409054 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C17_HUMAN (92-481): 4.34e-146: 426: 46.41
+	Hs
		408980 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C19_HUMAN (92-416): 8.2e-145: 422: 50.46
+	Hs
		280508 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT34_HUMAN (49-433): 1.3e-144: 421: 58.72
+	Hs
		408981 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C16_HUMAN (92-419): 2.79e-142: 418: 48.78
+	Hs
		444534 K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62		K1C17_HUMAN (92-481): 4.34e-146: 426: 46.41
+	Hs
		280507 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		KRT34_HUMAN (49-433): 1.3e-144: 421: 58.72
+	Hs
		409000 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C15_HUMAN (95-406): 2.34e-96: 300: 53.04
+	Hs
		408990 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C13_HUMAN (92-413): 5.09e-93: 291: 51.08
+	Hs
		49549 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		A1A4E9_HUMAN (92-413): 4.44e-92: 289: 50.46
+	Hs
		409082 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1H1_HUMAN (52-456): 1.54e-87: 276: 57.88
+	Hs
		280770 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT36_HUMAN (1-481): 1.02e-81: 262: 54.85
+	Hs
		409134 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C28_HUMAN (92-401): 1.25e-80: 259: 46.82
+	Hs
		409135 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C27_HUMAN (92-405): 2.13e-80: 259: 46.23
+	Hs
		409184 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT35_HUMAN (8-413): 3.25e-79: 255: 57.14
+	Hs
		409072 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1H2_HUMAN (3-416): 1.27e-78: 254: 57.79
+	Hs
		280845 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT37_HUMAN (8-423): 1.84e-70: 233: 49.30
+	Hs
		280943 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT38_HUMAN (13-415): 1e-70: 233: 51.82
+	Hs
		409116 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C40_HUMAN (3-419): 3.07e-70: 232: 52.63