HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27507811
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 522
+	Hs
		409288 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		380708 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		531648 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		409276 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		PZRN3_HUMAN (55-366): 6.23e-48: 180: 20.31
+	Hs
		301540 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		301560 K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Mm
		957023 KRT86_MOUSE (72-491): 3.78e-84: 274: 47.27		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Mm
		1141443 KRT81_MOUSE (72-491): 6.42e-84: 273: 47.03		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Mm
		1141414 KRT87_MOUSE (68-563): 6.13e-82: 268: 41.85		TRAF3_MOUSE (20-501): 4.18e-85: 275: 22.40
+	Hs
		301526 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		380552 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		318801 K2C75_HUMAN (1-582): 6e-90: 291: 53.58		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		380682 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		318774 K2C75_HUMAN (1-582): 6e-90: 291: 53.58		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		301586 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		301525 K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		531606 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		TRI58_HUMAN (62-403): 4.42e-43: 161: 11.67
+	Hs
		301515 K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		380469 K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		531626 K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00