Protein: RPA1
DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)

Gene: RPA1, POLR1A
Organism: Homo sapiens
Interactions: 162
UniProt ID: O95602

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001054 - RNA polymerase I activity
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003899 - DNA-directed 5'-3' RNA polymerase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317071

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

7

14

Small-scale

0.970

High

169756

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

7

18

Small-scale

0.968

High

317155

RPA49
DNA-directed RNA polymerase I subunit RPA49

8

3

Small-scale

0.968

High

317162

RPA2
DNA-directed RNA polymerase I subunit RPA2

8

20

Small-scale

0.967

High

317098

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

5

10

Small-scale

0.927

High

317094

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

5

10

Small-scale

0.922

High

317119

RPA43
DNA-directed RNA polymerase I subunit RPA43

4

1

High-throughput

0.903

High

317096

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

9

Small-scale

0.895

High

317173

RPA12
DNA-directed RNA polymerase I subunit RPA12

4

20

Small-scale

0.895

High

317172

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

4

2

Small-scale

0.881

High

317063

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

3

11

Small-scale

0.789

High

179508

RPA34
DNA-directed RNA polymerase I subunit RPA34

6

3

Small-scale

0.732

High

317101

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

4

11

Small-scale

0.694

High

295574

RMP
Unconventional prefoldin RPB5 interactor 1

4

2

Small-scale

0.686

High

317166

SIR7
NAD-dependent protein deacetylase sirtuin-7

4

5

Small-scale

0.676

High

317132

SKAP1
Src kinase-associated phosphoprotein 1

3

5

High-throughput

0.667

High

317176

UXT
Protein UXT

3

2

High-throughput

0.667

High

317120

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

1

0

High-throughput

0.656

High

317170

PIHD1
PIH1 domain-containing protein 1

5

3

High-throughput

0.656

High

317068

UBF1
Nucleolar transcription factor 1

3

4

Small-scale

0.640

High

317160

RPAP3
RNA polymerase II-associated protein 3

4

7

High-throughput

0.633

High

317164

GPN1
GPN-loop GTPase 1

2

9

High-throughput

0.628

High

155973

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

11

High-throughput

0.618

High

181375

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

8

High-throughput

0.618

High

270169

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

3

High-throughput

0.618

High

317070

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

18

High-throughput

0.618

High

317075

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

11

High-throughput

0.618

High

317079

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

20

High-throughput

0.618

High

317084

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

20

High-throughput

0.618

High

317095

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

11

High-throughput

0.618

High

317099

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

12

High-throughput

0.618

High

317133

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

3

High-throughput

0.618

High

317169

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

20

High-throughput

0.618

High

317191

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

20

High-throughput

0.618

High

317192

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

12

High-throughput

0.618

High

317102

CSK21
Casein kinase II subunit alpha

2

10

Small-scale

0.611

High

317161

WDR76
WD repeat-containing protein 76

2

9

High-throughput

0.611

High

317182

GPN3
GPN-loop GTPase 3

3

9

High-throughput

0.609

High

229264

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

2

8

Small-scale

0.584

High

317103

ERCC6
DNA excision repair protein ERCC-6

2

12

Small-scale

0.584

High

317093

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

0

High-throughput

0.576

High

87440

C9JLU1
RNA polymerase II, I and III subunit H

1

10

High-throughput

0.575

High

317066

ITF2
Transcription factor 4

1

1

High-throughput

0.573

High

317054

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

317108

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.561

High

317111

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

0

Small-scale

0.559

High

317153

MBB1A
Myb-binding protein 1A

2

0

Small-scale

0.559

High

171566

PFD6
Prefoldin subunit 6

2

3

High-throughput

0.558

High

317149

DAA10
Dynein axonemal assembly factor 10

2

2

High-throughput

0.558

High

317167

PDRG1
p53 and DNA damage-regulated protein 1

2

2

High-throughput

0.558

High

317181

PFD2
Prefoldin subunit 2

2

3

High-throughput

0.558

High

317104

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

317072

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.536

High

317080

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

317081

CADH5
Cadherin-5

1

1

High-throughput

0.536

High

317090

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.536

High

317106

SSRP1
FACT complex subunit SSRP1

1

10

Small-scale

0.536

High

317118

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.536

High

317129

SPT6H
Transcription elongation factor SPT6

1

5

High-throughput

0.536

High

317144

TRI52
E3 ubiquitin-protein ligase TRIM52

1

2

High-throughput

0.536

High

317187

RUVB2
RuvB-like 2

1

9

High-throughput

0.536

High

317188

RUVB1
RuvB-like 1

1

9

High-throughput

0.536

High

317193

SP16H
FACT complex subunit SPT16

1

2

Small-scale

0.536

High

317051

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

2

High-throughput

0.533

High

99498

F5H148
RNA polymerase I-specific transcription initiation factor RRN3

1

2

High-throughput

0.514

High

317115

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.513

High

317178

TRI10
Tripartite motif-containing protein 10

1

0

High-throughput

0.513

High

317180

PP13
Galactoside-binding soluble lectin 13

1

0

High-throughput

0.513

High

317097

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

317055

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

Small-scale

0.500

High

317158

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.493

High

317183

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

317145

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

317159

ASB7
Ankyrin repeat and SOCS box protein 7

1

2

High-throughput

0.489

High

317174

NHSL3
NHS-like protein 3

1

5

High-throughput

0.489

High

317177

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

246144

NBN
Nibrin

1

0

Small-scale

0.479

High

243753

BRD4
Bromodomain-containing protein 4

1

11

High-throughput

0.479

High

295480

RECQ5
ATP-dependent DNA helicase Q5

1

9

Small-scale

0.479

High

317053

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

317056

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

317057

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

3

High-throughput

0.479

High

317061

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

317065

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

High-throughput

0.479

High

317067

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

317073

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.479

High

317074

SCP2
Sterol carrier protein 2

1

1

High-throughput

0.479

High

317077

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

317082

H2B1B
Histone H2B type 1-B

1

11

High-throughput

0.479

High

317083

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

317085

BRCA1
Breast cancer type 1 susceptibility protein

1

4

Small-scale

0.479

High

317087

RECQ1
ATP-dependent DNA helicase Q1

1

8

High-throughput

0.479

High

317089

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

317092

CDK7
Cyclin-dependent kinase 7

1

8

High-throughput

0.479

High

317100

H4
Histone H4

1

4

High-throughput

0.479

High

317105

CSTF1
Cleavage stimulation factor subunit 1

1

5

Small-scale

0.479

High

317107

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

317109

TCOF
Treacle protein

1

3

Small-scale

0.479

High

317110

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

317112

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

8

Small-scale

0.479

High

317113

TNIP1
TNFAIP3-interacting protein 1

1

4

High-throughput

0.479

High

317123

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

10

High-throughput

0.479

High

317128

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

317134

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

317139

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

317140

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

317141

KAT2B
Histone acetyltransferase KAT2B

1

8

Small-scale

0.479

High

317142

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

317150

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

15

High-throughput

0.479

High

317151

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.479

High

317152

BARD1
BRCA1-associated RING domain protein 1

1

2

Small-scale

0.479

High

317156

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

317165

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

17

High-throughput

0.479

High

317168

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

3

High-throughput

0.479

High

317175

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

317179

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

317189

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

317190

NOP58
Nucleolar protein 58

1

3

Small-scale

0.479

High

317126

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

233127

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

317052

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.458

High

317114

TAF13
Transcription initiation factor TFIID subunit 13

1

0

High-throughput

0.458

High

317130

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

317138

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

317062

RPC22
Protein POLR1D, isoform 2

1

1

High-throughput

0.445

High

317064

RARA
Retinoic acid receptor alpha

1

5

Small-scale

0.445

High

317185

AGO1
Protein argonaute-1

1

6

High-throughput

0.445

High

317091

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

148249

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

255400

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

317058

YES
Tyrosine-protein kinase Yes

1

3

High-throughput

0.437

High

317059

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.437

High

317069

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.437

High

317086

TEC
Tyrosine-protein kinase Tec

1

3

High-throughput

0.437

High

317117

IKBB
NF-kappa-B inhibitor beta

1

1

High-throughput

0.437

High

317124

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.437

High

317125

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

2

High-throughput

0.437

High

317136

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

317154

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

317157

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

317184

FBW1B
F-box/WD repeat-containing protein 11

1

6

High-throughput

0.437

High

317186

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

305878

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.407

High

317131

Q86V94
LOC554223 protein

2

0

High-throughput

0.318

High

317147

DYDC2
DPY30 domain-containing protein 2

2

0

High-throughput

0.316

High

243085

DIAP2
Protein diaphanous homolog 2

1

0

High-throughput

0.279

Low

317076

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

317078

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

317088

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

317116

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.279

Low

317121

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.279

Low

317122

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

317135

TEX19
Testis-expressed protein 19

1

0

High-throughput

0.279

Low

317143

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

317148

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

317163

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.279

Low

317060

CLCA
Clathrin light chain A

1

0

High-throughput

0.269

Low

155232

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

317127

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

317137

KBTB8
Kelch repeat and BTB domain-containing protein 8

1

0

Small-scale

0.249

Low

317146

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

317171

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024