HitPredict

Interactor 1: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1363 Hs			1 4128
+	Hs
		729637 VGFR2_HUMAN (1-1346): 0: 879: 42.21		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		572617 VGFR1_HUMAN (19-1342): 0: 828: 38.63		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		665578 EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		452388 PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		738194 FLT3_HUMAN (837-1217): 1.41e-97: 338: 45.98		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		609246 FGFR3_HUMAN (310-670): 4.9e-27: 121: 13.53		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		601494 FGFR2_HUMAN (2-160): 1e-11: 71.9: 14.12		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		738299 FLT3_HUMAN (837-1217): 1.41e-97: 338: 45.98		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		872435 EPHA5_HUMAN (373-1199): 1.28e-153: 493: 13.44		ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42
+	Hs
		452416 PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80		ATR_HUMAN (3377-4128): 2.05e-122: 438: 19.28