HitPredict

Interactor 1: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1363 Hs			1 665
+	Hs
		557624 VGFR3_HUMAN (1-1363): 0: 982: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		729258 VGFR3_HUMAN (1-1363): 0: 982: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		557625 VGFR2_HUMAN (1-1346): 0: 879: 42.21		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		729636 VGFR2_HUMAN (1-1346): 0: 879: 42.21		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		665643 EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		452467 PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Dm
		112243 M9MRE1_DROME (24-1362): 0: 603: 18.36		CRK_DROME (3-162): 1.74e-11: 67: 29.76
+	Hs
		557643 EPHA5_HUMAN (373-1199): 1.28e-153: 493: 13.44		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		665574 EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		872422 EPHA5_HUMAN (373-1199): 1.28e-153: 493: 13.44		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		924590 EPHA7_HUMAN (392-1212): 1.3e-153: 492: 14.29		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		665389 EPHA3_HUMAN (386-1200): 1.47e-152: 489: 14.15		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		872621 EPHB2_MOUSE (372-1266): 9.54e-153: 489: 12.98		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		665608 EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		452344 PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		452385 PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		208979 PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		452342 PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		738192 FLT3_HUMAN (837-1217): 1.41e-97: 338: 45.98		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		208976 RET_HUMAN (801-1176): 1.25e-74: 273: 40.63		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77