HitPredict

Interactor 1: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.50	0.590

Property	Details
Experiments	21402774, 22711876
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1356 Hs			1 605
+	Hs
		729701 VGFR2_HUMAN (1-1356): 0: 1028: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		557285 PGFRA_HUMAN (11-545): 1.02e-53: 207: 19.71		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		427016 CSF1R_HUMAN (458-975): 2.36e-14: 80.4: 10.19		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		427014 CSF1R_HUMAN (458-975): 2.36e-14: 80.4: 10.19		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		729378 VGFR3_HUMAN (1-123): 1.31e-13: 78.1: 14.93		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		572595 VGFR1_HUMAN (1-131): 5.1e-20: 99.3: 13.38		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		738171 FLT3_HUMAN (40-555): 7.17e-20: 98.5: 16.22		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		609202 FGFR3_HUMAN (1-120): 8.75e-18: 91.6: 16.90		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37