Protein: 1433E
14-3-3 protein epsilon (14-3-3E)

Gene: 1433E, Ywhae
Organism: Mus musculus
Interactions: 187
UniProt ID: P62259

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001764 - neuron migration
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0004864 - protein phosphatase inhibitor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

967093

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

2

17

High-throughput

0.757

High

104490

SYGP1
Ras/Rap GTPase-activating protein SynGAP

4

7

High-throughput

0.694

High

972307

1433B
14-3-3 protein beta/alpha

1

19

Small-scale

0.691

High

972318

NDEL1
Nuclear distribution protein nudE-like 1

3

4

Small-scale

0.660

High

972235

DLG4
Disks large homolog 4

3

3

High-throughput

0.650

High

972203

ARG28
Rho guanine nucleotide exchange factor 28

1

9

Small-scale

0.647

High

972275

HDAC7
Histone deacetylase 7

3

12

Small-scale

0.631

High

972256

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

2

3

Small-scale

0.619

High

700334

BRAF
Serine/threonine-protein kinase B-raf

1

19

High-throughput

0.618

High

972199

1433Z
14-3-3 protein zeta/delta

1

19

High-throughput

0.618

High

972201

1433F
14-3-3 protein eta

1

19

High-throughput

0.618

High

972229

KSR1
Kinase suppressor of Ras 1

1

10

High-throughput

0.618

High

972224

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

13

Small-scale

0.612

High

972222

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

2

High-throughput

0.611

High

972310

DLGP1
Disks large-associated protein 1

2

1

High-throughput

0.611

High

972329

HOME1
Homer protein homolog 1

2

5

High-throughput

0.611

High

723723

CTND1
Catenin delta-1

2

4

Small-scale

0.584

High

651502

CBL
E3 ubiquitin-protein ligase CBL

2

5

High-throughput

0.571

High

772538

IRS1
Insulin receptor substrate 1

2

11

Small-scale

0.571

High

972301

RIN1
Ras and Rab interactor 1

1

6

Small-scale

0.552

High

972211

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

2

High-throughput

0.536

High

972238

CRK
Adapter molecule crk

1

4

High-throughput

0.536

High

972279

FTM
Protein fantom

1

5

High-throughput

0.536

High

972271

TBCD4
TBC1 domain family member 4

2

3

Small-scale

0.521

High

927667

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

972240

TFDP2
Transcription factor Dp-2

1

1

Small-scale

0.492

High

770520

RAB6A
Ras-related protein Rab-6A

1

1

High-throughput

0.481

High

972200

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

97731

E9PXB7
E3 ubiquitin-protein ligase

1

12

Small-scale

0.479

High

97770

E9PYF4
LIM domain only 7

1

6

High-throughput

0.479

High

147750

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

High-throughput

0.479

High

148475

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

11

High-throughput

0.479

High

266723

EF1B
Elongation factor 1-beta

1

2

High-throughput

0.479

High

312358

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

2

High-throughput

0.479

High

313039

DCX
Neuronal migration protein doublecortin

1

4

High-throughput

0.479

High

313306

SPD2A
SH3 and PX domain-containing protein 2A

1

6

High-throughput

0.479

High

480964

NUCL
Nucleolin

1

4

High-throughput

0.479

High

518668

EF1A1
Elongation factor 1-alpha 1

1

5

High-throughput

0.479

High

530753

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.479

High

547242

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.479

High

576858

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.479

High

576874

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.479

High

598659

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

8

High-throughput

0.479

High

749844

KIF5A
Kinesin heavy chain isoform 5A

1

7

High-throughput

0.479

High

861863

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

12

Small-scale

0.479

High

866570

CAZA1
F-actin-capping protein subunit alpha-1

1

2

High-throughput

0.479

High

866589

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.479

High

867571

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

877634

CBR1
Carbonyl reductase [NADPH] 1

1

2

High-throughput

0.479

High

878196

MPIP3
M-phase inducer phosphatase 3

1

10

Small-scale

0.479

High

908567

ADT2
ADP/ATP translocase 2

1

3

High-throughput

0.479

High

932540

DDX6
Probable ATP-dependent RNA helicase DDX6

1

9

High-throughput

0.479

High

940805

ATPB
ATP synthase F(1) complex catalytic subunit beta, mitochondrial

1

8

High-throughput

0.479

High

942998

FUS
RNA-binding protein FUS

1

3

High-throughput

0.479

High

968064

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

8

High-throughput

0.479

High

972194

EF1A2
Elongation factor 1-alpha 2

1

5

High-throughput

0.479

High

972195

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

972197

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

972198

CYH2
Cytohesin-2

1

4

High-throughput

0.479

High

972202

CASP3
Caspase-3

1

1

High-throughput

0.479

High

972204

MPRIP
Myosin phosphatase Rho-interacting protein

1

8

High-throughput

0.479

High

972206

MARK3
MAP/microtubule affinity-regulating kinase 3

1

20

High-throughput

0.479

High

972207

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

8

High-throughput

0.479

High

972208

NF1
Neurofibromin

1

6

High-throughput

0.479

High

972209

MARK2
Serine/threonine-protein kinase MARK2

1

20

High-throughput

0.479

High

972210

DMWD
Dystrophia myotonica WD repeat-containing protein

1

6

High-throughput

0.479

High

972213

Q3U2G2
Heat shock 70 kDa protein 4

1

8

High-throughput

0.479

High

972214

Q3UJF1
Histone deacetylase

1

12

High-throughput

0.479

High

972217

SRBS2
Sorbin and SH3 domain-containing protein 2

1

9

High-throughput

0.479

High

972219

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

2

High-throughput

0.479

High

972220

PACS2
Phosphofurin acidic cluster sorting protein 2

1

1

High-throughput

0.479

High

972223

BRSK1
Serine/threonine-protein kinase BRSK1

1

20

High-throughput

0.479

High

972225

GRDN
Girdin

1

6

High-throughput

0.479

High

972227

CAPR1
Caprin-1

1

4

High-throughput

0.479

High

972230

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.479

High

972232

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

972233

KINH
Kinesin-1 heavy chain

1

8

High-throughput

0.479

High

972236

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

972237

DBNL
Drebrin-like protein

1

3

High-throughput

0.479

High

972239

TFE3
Transcription factor E3

1

7

High-throughput

0.479

High

972241

NUAK1
NUAK family SNF1-like kinase 1

1

20

High-throughput

0.479

High

972242

SYN2
Synapsin-2

1

5

High-throughput

0.479

High

972243

CRTC1
CREB-regulated transcription coactivator 1

1

8

High-throughput

0.479

High

972244

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.479

High

972245

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.479

High

972246

GIT1
ARF GTPase-activating protein GIT1

1

8

High-throughput

0.479

High

972247

BRSK2
Serine/threonine-protein kinase BRSK2

1

20

High-throughput

0.479

High

972248

CE170
Centrosomal protein of 170 kDa

1

8

High-throughput

0.479

High

972249

DLGP3
Disks large-associated protein 3

1

1

High-throughput

0.479

High

972250

DCLK2
Serine/threonine-protein kinase DCLK2

1

11

High-throughput

0.479

High

972252

NEB2
Neurabin-2

1

7

High-throughput

0.479

High

972253

TAOK2
Serine/threonine-protein kinase TAO2

1

18

High-throughput

0.479

High

972254

R3HD2
R3H domain-containing protein 2

1

6

High-throughput

0.479

High

972255

RIMS3
Regulating synaptic membrane exocytosis protein 3

1

6

High-throughput

0.479

High

972257

FACD2
Fanconi anemia group D2 protein homolog

1

1

High-throughput

0.479

High

972259

RHG33
Rho GTPase-activating protein 33

1

9

High-throughput

0.479

High

972261

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

3

High-throughput

0.479

High

972262

WDR48
WD repeat-containing protein 48

1

8

High-throughput

0.479

High

972263

FRM4A
FERM domain-containing protein 4A

1

9

High-throughput

0.479

High

972265

BAIP2
BAR/IMD domain-containing adapter protein 2

1

2

High-throughput

0.479

High

972266

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

972267

FLNA
Filamin-A

1

2

High-throughput

0.479

High

972268

APH1A
Gamma-secretase subunit APH-1A

1

1

Small-scale

0.479

High

972269

LRCH3
DISP complex protein LRCH3

1

10

High-throughput

0.479

High

972272

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

972273

DOCK8
Dedicator of cytokinesis protein 8

1

5

High-throughput

0.479

High

972276

APH1B
Gamma-secretase subunit APH-1B

1

1

Small-scale

0.479

High

972277

WDR37
WD repeat-containing protein 37

1

5

High-throughput

0.479

High

972280

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.479

High

972281

TRI32
E3 ubiquitin-protein ligase TRIM32

1

4

High-throughput

0.479

High

972282

NAV1
Neuron navigator 1

1

5

High-throughput

0.479

High

972283

FBX4
F-box only protein 4

1

1

Small-scale

0.479

High

972284

MARK4
MAP/microtubule affinity-regulating kinase 4

1

20

High-throughput

0.479

High

972287

PACS1
Phosphofurin acidic cluster sorting protein 1

1

1

High-throughput

0.479

High

972289

ATAT
Alpha-tubulin N-acetyltransferase 1

1

1

High-throughput

0.479

High

972290

CBR3
Carbonyl reductase [NADPH] 3

1

2

High-throughput

0.479

High

972291

AHI1
Jouberin

1

7

High-throughput

0.479

High

972294

MARK1
Serine/threonine-protein kinase MARK1

1

18

High-throughput

0.479

High

972295

SFPQ
Splicing factor, proline- and glutamine-rich

1

6

High-throughput

0.479

High

972296

ACLY
ATP-citrate synthase

1

3

High-throughput

0.479

High

972298

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

10

High-throughput

0.479

High

972299

FRM4B
FERM domain-containing protein 4B

1

9

High-throughput

0.479

High

972302

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

6

High-throughput

0.479

High

972303

HOME3
Homer protein homolog 3

1

6

High-throughput

0.479

High

972304

NONO
Non-POU domain-containing octamer-binding protein

1

5

High-throughput

0.479

High

972305

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

8

High-throughput

0.479

High

972308

TBCD7
TBC1 domain family member 7

1

1

High-throughput

0.479

High

972311

EF1G
Elongation factor 1-gamma

1

7

High-throughput

0.479

High

972312

BORC5
BLOC-1-related complex subunit 5

1

1

High-throughput

0.479

High

972313

KLC4
Kinesin light chain 4

1

8

High-throughput

0.479

High

972314

TSC1
Hamartin

1

8

High-throughput

0.479

High

972315

WWTR1
WW domain-containing transcription regulator protein 1

1

14

Small-scale

0.479

High

972317

RIMS2
Regulating synaptic membrane exocytosis protein 2

1

10

High-throughput

0.479

High

972319

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

3

High-throughput

0.479

High

972320

LANC2
LanC-like protein 2

1

1

High-throughput

0.479

High

972321

DCLK1
Serine/threonine-protein kinase DCLK1

1

12

High-throughput

0.479

High

972324

SRCN1
SRC kinase signaling inhibitor 1

1

1

High-throughput

0.479

High

972326

DREB
Drebrin

1

5

High-throughput

0.479

High

972327

PSA1
Proteasome subunit alpha type-1

1

2

High-throughput

0.479

High

108575

G3X9H5
Huntingtin

1

0

High-throughput

0.458

High

204757

EXOC4
Exocyst complex component 4

1

0

High-throughput

0.458

High

420085

PRIO
Major prion protein

1

0

Small-scale

0.458

High

840616

PURA
Transcriptional activator protein Pur-alpha

1

0

High-throughput

0.458

High

972196

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

972212

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.458

High

972292

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.458

High

972293

CACB1
Voltage-dependent L-type calcium channel subunit beta-1

1

0

High-throughput

0.458

High

972297

MSD4
Myb/SANT-like DNA-binding domain-containing protein 4

1

0

High-throughput

0.458

High

972323

ITA2B
Integrin alpha-IIb

1

1

High-throughput

0.457

High

972300

SH3B4
SH3 domain-binding protein 4

1

2

Small-scale

0.457

High

59468

A2AKD7
Alpha-1-syntrophin

1

3

High-throughput

0.445

High

98050

DESP
Desmoplakin

1

5

High-throughput

0.445

High

148166

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.445

High

883756

CENPC
Centromere protein C

1

2

High-throughput

0.445

High

972205

THIOM
Thioredoxin, mitochondrial

1

2

High-throughput

0.445

High

972226

LCP2
Lymphocyte cytosolic protein 2

1

5

High-throughput

0.445

High

972228

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

High-throughput

0.445

High

972264

COX15
Heme A synthase COX15

1

1

High-throughput

0.445

High

972286

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.445

High

972309

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.445

High

972316

XPO7
Exportin-7

1

1

High-throughput

0.445

High

972328

HDAC5
Histone deacetylase 5

1

12

High-throughput

0.445

High

59040

TANC2
Protein TANC2

1

6

High-throughput

0.437

High

59181

A2A9M5
Dedicator of cytokinesis 7

1

5

High-throughput

0.437

High

108987

RFIP2
Rab11 family-interacting protein 2

1

10

High-throughput

0.437

High

313173

SYN1
Synapsin-1

1

7

High-throughput

0.437

High

858161

AINX
Alpha-internexin

1

4

High-throughput

0.437

High

958546

ACTZ
Alpha-centractin

1

5

High-throughput

0.437

High

972215

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

8

High-throughput

0.437

High

972218

K22O
Keratin, type II cytoskeletal 2 oral

1

2

High-throughput

0.437

High

972221

Q3ZB59
Growth factor receptor bound protein 2-associated protein 2

1

9

High-throughput

0.437

High

972234

CP131
Centrosomal protein of 131 kDa

1

5

High-throughput

0.437

High

972251

ERC2
ERC protein 2

1

6

High-throughput

0.437

High

972258

Q80VE5
TBC1 domain family, member 22B

1

5

High-throughput

0.437

High

972260

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

7

High-throughput

0.437

High

972285

SYN3
Synapsin-3

1

5

High-throughput

0.437

High

972288

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.437

High

972306

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.437

High

972322

GIT2
ARF GTPase-activating protein GIT2

1

8

High-throughput

0.437

High

972325

KI21B
Kinesin-like protein KIF21B

1

7

High-throughput

0.437

High

905802

CAV3
Caveolin-3

1

0

High-throughput

0.426

High

972231

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.407

High

972278

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

12

Small-scale

0.407

High

398242

CFAD
Complement factor D

1

0

High-throughput

0.249

Low

972216

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

High-throughput

0.249

Low

972270

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.249

Low

972274

VP9D1
VPS9 domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025