HitPredict

Interactor 1: AP1B1 (P36000)
AP-1 complex subunit beta-1 (Beta-1-adaptin) (Clathrin assembly protein complex 1 beta-1 large chain) (Clathrin assembly protein large beta-1 chain)
Gene: APL2

Interactor 2: AP2S (Q00381)
AP-2 complex subunit sigma (Adaptin small chain) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: APS2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	10564262
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 726 Sc			1 147
+	Hs
		926066 AP2B1_HUMAN (21-726): 0: 636: 34.41		AP1M2_HUMAN (1-147): 6.51e-46: 155: 16.89
+	Hs
		925992 AP2B1_HUMAN (21-726): 0: 636: 34.41		AP1M1_HUMAN (1-142): 6.09e-45: 153: 14.79
+	Hs
		880408 AP2B1_HUMAN (21-726): 0: 636: 34.41		AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00
+	Hs
		1014107 AP1B1_HUMAN (21-726): 0: 630: 35.79		AP1M2_HUMAN (1-147): 6.51e-46: 155: 16.89
+	Hs
		903681 AP2B1_HUMAN (21-726): 0: 636: 34.41		AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93
+	Hs
		1014074 AP1B1_HUMAN (21-726): 0: 630: 35.79		AP1M1_HUMAN (1-142): 6.09e-45: 153: 14.79
+	Hs
		880409 AP1B1_HUMAN (21-726): 0: 630: 35.79		AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00
+	Hs
		925978 AP2B1_HUMAN (21-726): 0: 636: 34.41		AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76
+	Hs
		903682 AP1B1_HUMAN (21-726): 0: 630: 35.79		AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93
+	Hs
		864065 AP2B1_HUMAN (21-726): 0: 636: 34.41		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97
+	Hs
		1014066 AP1B1_HUMAN (21-726): 0: 630: 35.79		AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76
+	Hs
		864070 AP1B1_HUMAN (21-726): 0: 630: 35.79		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97
+	Dm
		1096906 Q24253_DROME (21-690): 0: 589: 34.99		Q9VDC3_DROME (3-147): 3.36e-43: 141: 48.28
+	Ce
		725358 Q9N4F3_CAEEL (21-685): 0: 573: 34.53		AP1M_CAEEL (1-142): 1.87e-43: 149: 18.31
+	Sc
		715570 AP1B1_YEAST (1-726): 0: 584: 100.00		AP1S1_YEAST (3-147): 2.75e-41: 136: 36.74
+	Mm
		612130 AP1G1_MOUSE (3-720): 0: 557: 13.89		AP1M1_MOUSE (1-142): 5.37e-45: 153: 14.79
+	Hs
		212611 AP1G1_HUMAN (3-720): 0: 555: 13.89		AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00
+	Hs
		212614 AP1G1_HUMAN (3-720): 0: 555: 13.89		AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93
+	At
		1196570 APBLB_ARATH (21-701): 0: 568: 36.30		AP2S_ARATH (3-147): 1.28e-40: 134: 48.97
+	Hs
		212608 AP1G1_HUMAN (3-720): 0: 555: 13.89		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97