HitPredict

Interactor 1: SET3 (P36124)
SET domain-containing protein 3
Gene: SET3

Interactor 2: LST8 (P41318)
Target of rapamycin complex subunit LST8 (TORC subunit LST8) (Lethal with SEC13 protein 8)
Gene: LST8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	21179020
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 751 Sc			1 303
+	Sc
		733238 SET3_YEAST (1-751): 0: 685: 100.00		TAF5_YEAST (205-301): 2.38e-09: 60.1: 35.05
+	Hs
		1288292 NSD3_HUMAN (78-556): 5.55e-75: 266: 13.05		SNR40_HUMAN (191-298): 3.25e-27: 110: 24.07
+	Hs
		331862 NSD2_HUMAN (122-556): 4.59e-74: 264: 13.29		SNR40_HUMAN (191-298): 3.25e-27: 110: 24.07
+	Hs
		331893 NSD2_HUMAN (122-556): 4.59e-74: 264: 13.29		DTL_HUMAN (40-290): 3.68e-16: 80.5: 26.25
+	Hs
		903149 KMT2A_HUMAN (25-480): 9.79e-60: 222: 14.56		WDR5_HUMAN (194-302): 1.5e-30: 118: 28.44
+	Hs
		975304 KMT2A_HUMAN (25-480): 9.79e-60: 222: 14.56		SNR40_HUMAN (191-298): 3.25e-27: 110: 24.07
+	Hs
		903604 KMT2B_HUMAN (26-480): 9.72e-50: 191: 13.06		WDR5_HUMAN (194-302): 1.5e-30: 118: 28.44
+	Hs
		1288387 KMT2B_HUMAN (26-480): 9.72e-50: 191: 13.06		SNR40_HUMAN (191-298): 3.25e-27: 110: 24.07
+	Hs
		1288291 SETD2_HUMAN (164-702): 1.1e-47: 185: 12.46		SNR40_HUMAN (191-298): 3.25e-27: 110: 24.07
+	Hs
		203735 SUV91_HUMAN (301-507): 1.13e-51: 187: 17.14		DAW1_HUMAN (174-302): 3.54e-26: 108: 22.22
+	At
		1319861 ATX1_ARATH (97-496): 7.97e-64: 232: 13.40		WDR5A_ARATH (238-301): 6.7e-10: 60.7: 30.44
+	Hs
		1317584 SETD2_HUMAN (164-702): 1.1e-47: 185: 12.46		NLE1_HUMAN (233-302): 2.79e-17: 83.5: 28.57
+	Dm
		1358851 MBDR2_DROME (30-221): 4.75e-35: 145: 21.03		WDS_DROME (194-302): 2.39e-29: 116: 28.44
+	Hs
		903609 SET1B_HUMAN (210-477): 3.99e-27: 120: 14.44		WDR5_HUMAN (194-302): 1.5e-30: 118: 28.44
+	Hs
		903374 KMT2C_HUMAN (187-476): 3.3e-26: 118: 15.52		WDR5_HUMAN (194-302): 1.5e-30: 118: 28.44
+	Mm
		903669 KMT2C_MOUSE (187-476): 2.46e-26: 118: 15.52		WDR5_MOUSE (194-302): 1.5e-30: 118: 28.44
+	Hs
		152622 KMT2D_HUMAN (259-476): 5.94e-26: 117: 17.73		WDR5_HUMAN (194-302): 1.5e-30: 118: 28.44
+	Hs
		152663 KMT2D_HUMAN (259-476): 5.94e-26: 117: 17.73		WDR5B_HUMAN (193-302): 2.46e-29: 115: 29.09
+	Hs
		68281 P20L1_HUMAN (81-180): 3.41e-24: 110: 23.00		WDR5_HUMAN (194-302): 1.5e-30: 118: 28.44
+	Sp
		195053 SET1_SCHPO (311-477): 1.1e-27: 122: 17.96		SWD3_SCHPO (14-285): 2.08e-09: 59.7: 20.40