HitPredict

Interactor 1: PRS4 (P36612)
26S proteasome regulatory subunit 4 homolog (Protein mts2)
Gene: mts2

Interactor 2: PSA4 (Q10329)
Probable proteasome subunit alpha type-4
Gene: pre6

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	20133687, 24938783
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 448 Sp			1 259
+	Hs
		156245 PRS6B_HUMAN (68-440): 8.65e-160: 459: 51.47		PSA7_HUMAN (4-230): 8.52e-97: 285: 54.59
+	Hs
		637354 PRS6B_HUMAN (68-440): 8.65e-160: 459: 51.47		PSA1_HUMAN (2-259): 1.01e-93: 278: 27.27
+	Hs
		656167 PRS6B_HUMAN (68-440): 8.65e-160: 459: 51.47		PSA5_HUMAN (2-232): 7.74e-94: 277: 34.03
+	Hs
		798626 PRS6B_HUMAN (68-440): 8.65e-160: 459: 51.47		PSA6_HUMAN (2-236): 7.16e-90: 267: 29.88
+	At
		286451 PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66		PSA6A_ARATH (2-235): 1.46e-104: 305: 31.67
+	At
		189237 PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66		PSA7B_ARATH (1-250): 4.99e-98: 288: 54.58
+	At
		672533 PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66		PSA7A_ARATH (1-229): 1.02e-95: 282: 56.09
+	At
		286460 PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66		PSA5A_ARATH (2-232): 7.86e-95: 280: 34.75
+	At
		1114627 PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66		PSA5B_ARATH (2-232): 1.92e-94: 278: 33.90
+	Hs
		156269 PRS4_HUMAN (50-444): 1.39e-124: 370: 74.50		PSA7_HUMAN (4-230): 8.52e-97: 285: 54.59
+	At
		188699 PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66		PSA2A_ARATH (2-233): 5.15e-93: 275: 35.47
+	At
		1225875 PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66		PSA2B_ARATH (2-233): 4.38e-92: 272: 35.47
+	At
		286458 PRS4A_ARATH (1-444): 7.61e-128: 379: 69.66		PSA4A_ARATH (3-231): 1.35e-91: 272: 33.33
+	Dm
		820495 PRS4_DROME (8-444): 2.11e-125: 372: 73.52		PSA5_DROME (2-233): 1.76e-93: 277: 34.44
+	Hs
		637380 PRS4_HUMAN (50-444): 1.39e-124: 370: 74.50		PSA1_HUMAN (2-259): 1.01e-93: 278: 27.27
+	Dm
		611634 PRS4_DROME (8-444): 2.11e-125: 372: 73.52		PSA71_DROME (2-229): 8.62e-91: 270: 52.61
+	Hs
		637642 PRS6B_HUMAN (68-440): 8.65e-160: 459: 51.47		PSA2_HUMAN (3-210): 2.47e-45: 153: 38.10
+	Dm
		771301 Q8SZ19_DROME (63-441): 1.66e-139: 407: 40.53		PSA2_DROME (4-212): 3.06e-48: 161: 37.92
+	Dm
		771287 PRS4_DROME (8-444): 2.11e-125: 372: 73.52		PSA2_DROME (4-212): 3.06e-48: 161: 37.92
+	Hs
		637667 PRS4_HUMAN (50-444): 1.39e-124: 370: 74.50		PSA2_HUMAN (3-210): 2.47e-45: 153: 38.10