HitPredict

Interactor 1: FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Gene: FLT3

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10080542
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 993 Hs			1 217
+	Hs
		411619 FLT3_HUMAN (1-993): 0: 844: 97.89		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337376 FLT3_HUMAN (1-993): 0: 844: 97.89		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		738170 FLT3_HUMAN (1-993): 0: 844: 97.89		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		412062 FLT3_HUMAN (1-993): 0: 844: 97.89		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433274 FLT3_HUMAN (1-993): 0: 844: 97.89		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		454802 FLT3_HUMAN (1-993): 0: 844: 97.89		FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45
+	Hs
		442785 FLT3_HUMAN (1-993): 0: 844: 97.89		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433624 FLT3_HUMAN (1-993): 0: 844: 97.89		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522826 FLT3_HUMAN (1-993): 0: 844: 97.89		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		403541 KIT_MOUSE (57-986): 0: 600: 30.08		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		557088 PGFRA_HUMAN (47-992): 0: 595: 27.21		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411567 KIT_HUMAN (57-986): 0: 594: 30.44		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337322 KIT_HUMAN (57-986): 0: 594: 30.44		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		403536 KIT_MOUSE (57-986): 0: 600: 30.08		VAV_MOUSE (2-60): 8.53e-15: 74.6: 42.37
+	Hs
		411962 KIT_HUMAN (57-986): 0: 594: 30.44		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433226 KIT_HUMAN (57-986): 0: 594: 30.44		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Mm
		292679 KIT_MOUSE (57-986): 0: 600: 30.08		GRAP2_MOUSE (3-55): 1.57e-10: 61.5: 37.74
+	Hs
		433539 KIT_HUMAN (57-986): 0: 594: 30.44		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Rn
		595729 PGFRA_RAT (51-992): 0: 594: 27.00		LYN_RAT (129-215): 4.14e-11: 63.4: 23.60
+	Hs
		275165 KIT_HUMAN (57-986): 0: 594: 30.44		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62