HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: TGFR2 (P37173)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: TGFBR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 25825445, 7890683, 35721120, 36889311, 21791611, 19758997, 19556242, 11483955, 33961781, 7878020, 10026191, 23868260, 18243111
Identification Methods affinity chromatography technology, two hybrid, coimmunoprecipitation, anti bait coimmunoprecipitation, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~ecTbetaR2, PK_Tyr_Ser-Thr~Pkinase, PK_Tyr_Ser-Thr~TGF_beta_GS
Common GO terms GO:0001701 - in utero embryonic development
GO:0001837 - epithelial to mesenchymal transition
GO:0002088 - lens development in camera-type eye
GO:0004675 - transmembrane receptor protein serine/threonine kinase activity
GO:0005024 - transforming growth factor beta receptor activity
and 24 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 503
Hs

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Last updated: 15 Jul 2024