HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: FKB1A (P62942)
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
Gene: FKBP1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.944

Property	Details
Experiments	7518616, 7791754, 36889311, 16049346, 10025408, 24658140
Identification Methods	two hybrid, affinity chromatography technology, pull down, x-ray crystallography, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase, FKBP_C~TGF_beta_GS
Common GO terms	GO:0016020 - membrane GO:0070411 - I-SMAD binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 108
+	Hs
		738525 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33
+	Hs
		923822 ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		738325 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		738439 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		738328 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33
+	Hs
		739522 ACVL1_HUMAN (6-498): 2.71e-130: 389: 47.21		FKB1A_HUMAN (1-108): 2e-54: 166: 100.00
+	Hs
		1034871 AMHR2_HUMAN (205-499): 3.07e-44: 166: 33.87		FKBP5_HUMAN (2-108): 3.73e-15: 71.3: 28.44