HitPredict

Interactor 1: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.741

Property	Details
Experiments	26679521, 11163210, 35017630, 22624557, 25149540, 31746425, 21791611, 23973329
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0045121 - membrane raft GO:0046332 - SMAD binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 503 Hs			1 748
+	Mm
		56831 TGFR1_MOUSE (26-503): 1.83e-145: 428: 97.30		SMUF2_MOUSE (1-748): 0: 835: 99.20
+	Hs
		740064 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		SMUF2_HUMAN (1-748): 0: 834: 100.00
+	Hs
		738579 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		981139 ACVR1_HUMAN (10-500): 8.17e-136: 403: 49.30		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		122298 BMR1B_HUMAN (22-503): 1.21e-134: 400: 51.53		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		738413 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		738495 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Mm
		1143778 TGFR2_MOUSE (38-499): 3.76e-121: 368: 32.23		SMUF1_MOUSE (1-748): 0: 761: 73.01
+	Hs
		740065 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		738509 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		1046388 BMPR2_HUMAN (48-495): 1.21e-92: 305: 29.21		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		738312 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		738403 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		738485 ACV1B_HUMAN (2-503): 6.8e-133: 396: 67.78		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		738569 TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		125195 BMR1A_HUMAN (21-503): 4.05e-134: 400: 50.92		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Dm
		1279501 Q95SI0_DROME (31-497): 6.57e-122: 368: 45.13		SMUF1_DROME (7-225): 1.83e-30: 131: 48.70
+	Hs
		125199 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		740040 TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44