HitPredict

Interactor 1: RPB9 (P36954)
DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)
Gene: POLR2I

Interactor 2: RPB11 (P52435)
DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit)
Gene: POLR2J

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	24981860, 35271311, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003899 - DNA-directed 5'-3' RNA polymerase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005665 - RNA polymerase II, core complex GO:0006366 - transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 125 Hs			1 117
+	Hs
		854498 RPC10_HUMAN (14-125): 6.76e-35: 117: 26.79		RPB11_HUMAN (1-117): 1.88e-53: 164: 100.00
+	Sc
		655559 RPB9_YEAST (11-124): 3.78e-38: 126: 43.86		RPB11_YEAST (1-110): 4.2e-45: 144: 50.00
+	Hs
		854489 RPA12_HUMAN (12-125): 2.72e-23: 89: 16.67		RPB11_HUMAN (1-117): 1.88e-53: 164: 100.00
+	Hs
		484501 RPC10_HUMAN (14-125): 6.76e-35: 117: 26.79		RPAC2_HUMAN (12-116): 3.57e-40: 131: 30.56
+	Hs
		854420 TCEA2_HUMAN (57-124): 4.18e-14: 68.6: 22.06		RPB11_HUMAN (1-117): 1.88e-53: 164: 100.00
+	Sc
		425468 TFS2_YEAST (41-124): 2.88e-19: 82.5: 17.86		RPB11_YEAST (1-110): 4.2e-45: 144: 50.00
+	Sc
		655651 RPC10_YEAST (14-125): 3.41e-32: 111: 27.43		RPAC2_YEAST (13-110): 5.03e-33: 114: 33.33
+	Sc
		655595 RPA12_YEAST (11-124): 1.49e-22: 87.1: 15.70		RPAC2_YEAST (13-110): 5.03e-33: 114: 33.33