HitPredict

Interactor 1: SCNNB (P37090)
Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: Scnn1b

Interactor 2: NEDD4 (Q62940)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4)
Gene: NEDD4

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	8665844, 9923703, 12654927
Identification Methods	two hybrid, pull down, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006814 - sodium ion transport GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Rn			1 887
+	Mm
		808382 SCNNB_MOUSE (1-638): 0: 724: 96.71		NEDD4_MOUSE (1-887): 0: 910: 94.59
+	Rn
		739625 SCNNA_RAT (21-638): 0: 592: 32.12		NEDD4_RAT (1-887): 0: 927: 100.00
+	Rn
		739631 SCNNG_RAT (16-623): 0: 589: 36.80		NEDD4_RAT (1-887): 0: 927: 100.00
+	Mm
		808356 SCNNA_MOUSE (21-637): 0: 595: 32.07		NEDD4_MOUSE (1-887): 0: 910: 94.59
+	Mm
		1208291 SCNNB_MOUSE (1-638): 0: 724: 96.71		NED4L_MOUSE (72-887): 0: 769: 57.23
+	Hs
		845978 SCNNB_HUMAN (1-638): 0: 719: 83.44		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		808049 SCNNB_HUMAN (1-638): 0: 719: 83.44		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Hs
		845977 SCNNB_HUMAN (1-638): 0: 719: 83.44		ITCH_HUMAN (62-884): 0: 686: 31.69
+	Hs
		125256 SCNNB_HUMAN (1-638): 0: 719: 83.44		WWP2_HUMAN (72-884): 0: 677: 33.30
+	Mm
		93285 SCNNB_MOUSE (1-638): 0: 724: 96.71		E9PXB7_MOUSE (169-887): 0: 651: 57.16
+	Hs
		739604 SCNNA_HUMAN (21-625): 0: 602: 31.55		NED4L_HUMAN (58-887): 0: 770: 56.21
+	Hs
		739582 SCNNA_HUMAN (21-625): 0: 602: 31.55		NEDD4_HUMAN (154-887): 0: 724: 78.86
+	Hs
		739603 SCNNA_HUMAN (21-625): 0: 602: 31.55		ITCH_HUMAN (62-884): 0: 686: 31.69
+	Hs
		125197 SCNNA_HUMAN (21-625): 0: 602: 31.55		WWP2_HUMAN (72-884): 0: 677: 33.30
+	Rn
		739630 SCNNG_RAT (16-623): 0: 589: 36.80		Q4V8H7_RAT (67-884): 0: 670: 32.03
+	Mm
		93272 SCNNA_MOUSE (21-637): 0: 595: 32.07		E9PXB7_MOUSE (169-887): 0: 651: 57.16
+	Hs
		739608 SCNNA_HUMAN (21-625): 0: 602: 31.55		WWP1_HUMAN (76-884): 0: 642: 31.52
+	Hs
		739597 SCNNA_HUMAN (21-625): 0: 602: 31.55		HUWE1_HUMAN (158-885): 2.08e-167: 542: 27.96
+	Hs
		845975 SCNNB_HUMAN (1-638): 0: 719: 83.44		HECW1_HUMAN (22-500): 2.12e-18: 93: 13.24
+	Hs
		739596 SCNNA_HUMAN (21-625): 0: 602: 31.55		HECW1_HUMAN (22-500): 2.12e-18: 93: 13.24