Protein: XPP1
Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)

Gene: XPP1, XPNPEP1
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q9NQW7

Gene Ontology (top 5):
GO:0004177 - aminopeptidase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0010815 - bradykinin catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1409753

SPI2B
Spindlin-2B

3

2

High-throughput

0.667

High

944164

WDR4
tRNA

2

5

High-throughput

0.628

High

1151892

RHOH
Rho-related GTP-binding protein RhoH

2

3

High-throughput

0.606

High

962527

RHOA
Transforming protein RhoA

2

2

High-throughput

0.601

High

1447523

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.590

High

999622

HBG2
Hemoglobin subunit gamma-2

2

0

High-throughput

0.580

High

853853

MK09
Mitogen-activated protein kinase 9

1

3

High-throughput

0.541

High

387901

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.536

High

1153025

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

106699

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

1122775

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.518

High

611987

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

616811

SDC1
Syndecan-1

1

0

High-throughput

0.513

High

1339579

STXB6
Syntaxin-binding protein 6

1

0

High-throughput

0.513

High

891811

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.508

High

508683

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

895839

CSRP3
Cysteine and glycine-rich protein 3

1

0

High-throughput

0.493

High

1386891

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.493

High

718471

CD6
T-cell differentiation antigen CD6

1

1

High-throughput

0.489

High

725170

HXC12
Homeobox protein Hox-C12

1

3

High-throughput

0.489

High

352733

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

957210

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

0

High-throughput

0.486

High

243026

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

831484

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

347945

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

386267

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.479

High

401548

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

412660

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

1115082

CUL4A
Cullin-4A

1

7

High-throughput

0.479

High

1255682

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1447527

PKHG1
Pleckstrin homology domain-containing family G member 1

1

1

High-throughput

0.479

High

446058

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

537962

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

1414915

DUS26
Dual specificity protein phosphatase 26

1

0

High-throughput

0.458

High

964467

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.457

High

142423

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.445

High

388015

FIBG
Fibrinogen gamma chain

1

2

High-throughput

0.445

High

530420

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

1178097

RN151
RING finger protein 151

1

1

High-throughput

0.445

High

1209694

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1447524

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

1238610

RINT1
RAD50-interacting protein 1

1

0

High-throughput

0.438

High

589784

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

696598

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

769267

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

404923

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1164402

TPD53
Tumor protein D53

1

0

High-throughput

0.426

High

1315717

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

1382670

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

1405170

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.426

High

1447528

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

1447529

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.426

High

330331

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.407

High

689861

CD27
CD27 antigen

1

1

High-throughput

0.407

High

1328132

TTC9C
Tetratricopeptide repeat protein 9C

1

1

High-throughput

0.407

High

1392413

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.407

High

1153510

RAB30
Ras-related protein Rab-30

2

0

High-throughput

0.328

High

1436691

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.316

High

71476

P20L1
PHD finger protein 20-like protein 1

1

0

High-throughput

0.279

Low

74142

VWC2L
von Willebrand factor C domain-containing protein 2-like

1

0

High-throughput

0.279

Low

1399229

GUCD1
Protein GUCD1

1

0

High-throughput

0.279

Low

1447525

GDE1
Glycerophosphodiester phosphodiesterase 1

1

0

High-throughput

0.279

Low

353573

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

643088

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

1104122

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1121018

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

High-throughput

0.232

Low

1358205

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

1435013

TM231
Transmembrane protein 231

1

0

High-throughput

0.232

Low

1447526

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.232

Low

1447530

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025