HitPredict

Interactor 1: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	24368734, 19047629
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 538
+	Hs
		369650 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Mm
		1142679 ERR2_MOUSE (25-502): 1.44e-103: 318: 19.75		RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07
+	Hs
		782547 HNF4A_HUMAN (114-501): 4.62e-100: 311: 21.34		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		369932 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		WDR5B_HUMAN (2-225): 9.91e-62: 207: 16.88
+	Hs
		740487 PPARG_HUMAN (1-505): 2.47e-165: 479: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		369721 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		SMU1_HUMAN (179-320): 3.28e-21: 99: 13.79
+	Hs
		1269746 ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70		NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38
+	Hs
		488008 RARA_HUMAN (45-503): 3.89e-102: 316: 25.22		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		1103005 ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70		SMU1_HUMAN (179-320): 3.28e-21: 99: 13.79
+	Hs
		369305 ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		377562 GCR_HUMAN (18-503): 1.99e-98: 315: 17.85		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		1269553 ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70		WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67
+	Hs
		611472 NR4A1_HUMAN (4-503): 3.33e-99: 312: 20.83		PHIP_HUMAN (227-374): 6.69e-15: 80.4: 13.91
+	Mm
		903664 ERR2_MOUSE (25-502): 1.44e-103: 318: 19.75		WDR5_MOUSE (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		782513 HNF4A_HUMAN (114-501): 4.62e-100: 311: 21.34		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		903403 ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		903650 NR2E3_HUMAN (99-503): 1.87e-95: 297: 22.17		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41